{"id":"W2020852111","doi":"10.1074/jbc.m113.529743","title":"Dynamics of Hepatitis C Virus (HCV) RNA-dependent RNA Polymerase NS5B in Complex with RNA","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"NS5B; RNA; RNA-dependent RNA polymerase; RNA polymerase; Hepatitis C virus; Polymerase; Biology; Molecular biology; Chemistry; Population; Biophysics; Biochemistry; Enzyme; Virology; Virus; Gene; Hepacivirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646289,0.0002254004,0.0003509247,0.0002195624,0.0002748902,0.0004107916,0.0003056384,0.0002821021,0.0009153778],"category_scores_gemma":[0.0003898084,0.0001563964,0.000200234,0.0002079921,0.000249127,0.0002996704,0.0002674338,0.0003620561,0.0002436558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004624312,"about_ca_system_score_gemma":0.0001406599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002085442,"about_ca_topic_score_gemma":0.001756116,"domain_scores_codex":[0.9997688,0.00002467107,0.00001208755,0.00007801234,0.00008479077,0.00003181174],"domain_scores_gemma":[0.9998614,0.00003426223,0.00003686283,0.000006874295,0.00002601095,0.00003462761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003089583,0.00008920318,0.005425218,0.0001170442,0.00006976356,0.0002107799,0.0003231697,0.001762563,0.9881656,0.0003120837,0.0002486817,0.00296685],"study_design_scores_gemma":[0.0000641708,0.0007910532,0.1016406,0.00004258779,0.0001169831,0.0008534186,0.0005032889,0.1682946,0.7217678,0.0004125344,0.00540434,0.0001085178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974529,0.0004870196,0.001204374,0.00006196457,0.000007794079,0.000008560431,0.0001252815,0.00003689896,0.0006151994],"genre_scores_gemma":[0.9978989,0.0002939391,0.0008326691,0.00002666791,0.000004834226,0.00001303226,0.0003019149,0.00001769028,0.0006102759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002085442,"threshold_uncertainty_score":0.004146636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03557744976944369,"score_gpt":0.3059659785907792,"score_spread":0.2703885288213355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}