{"id":"W2020913692","doi":"10.1016/s0024-3205(00)00456-2","title":"Supraphysiological level of estrogen exposure in vivo increases lymphoid cell death in mice","year":2000,"lang":"en","type":"article","venue":"Life Sciences","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ovariectomized rat; Internal medicine; Endocrinology; Splenocyte; Apoptosis; In vivo; Estrogen; Spleen; DNA fragmentation; Necrosis; Biology; Chemistry; Programmed cell death; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322664,0.0001050562,0.0001438393,0.00006292587,0.00004050519,0.000007073452,0.0002539565,0.0001414806,0.00006233003],"category_scores_gemma":[0.00004594626,0.00007946691,0.00005872631,0.0002694921,0.0002084696,0.00000651011,0.0000410611,0.00006197711,0.000006201007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005408214,"about_ca_system_score_gemma":0.0001274583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004388471,"about_ca_topic_score_gemma":0.00003137168,"domain_scores_codex":[0.9990593,0.0001011297,0.0001929782,0.0002914378,0.0001214232,0.0002337014],"domain_scores_gemma":[0.9997407,0.00002900503,0.00004275015,0.0001071171,0.00001221742,0.00006823587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008581929,0.0002081443,0.1984071,0.000008769334,0.000005427332,0.000006900314,0.00003786312,0.000644868,0.8000327,0.00004059261,0.0001566034,0.0003652764],"study_design_scores_gemma":[0.000940536,0.001041891,0.06635031,0.00003239009,0.000007115116,0.00001813244,0.0001527287,0.000190736,0.9303182,0.0001152017,0.0006129651,0.0002197541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944589,0.002845412,0.0000020509,0.00002433621,0.00002962245,0.00009163106,0.00001499355,0.000004307085,0.002528781],"genre_scores_gemma":[0.9984891,0.0007400273,0.0004509072,0.0001077309,0.00004288232,0.000007509206,0.000006707799,0.000003966735,0.0001511969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1320568,"threshold_uncertainty_score":0.3240567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02231664674684452,"score_gpt":0.2567033251823679,"score_spread":0.2343866784355234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}