{"id":"W2020956187","doi":"10.1083/jcb.153.4.773","title":"Synergism of Xist Rna, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation","year":2001,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":490,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institutes of Health; National Cancer Institute; W. M. Keck Foundation","keywords":"XIST; Biology; X-inactivation; Chromatin; Molecular biology; Histone methylation; DNA methylation; Trichostatin A; Histone H2A; Histone; Genetics; Cell biology; X chromosome; Histone deacetylase; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005119165,0.00007525421,0.0001611335,0.00006118792,0.00003687367,0.000003871197,0.0001083197,0.00010171,0.00002706672],"category_scores_gemma":[0.00009493273,0.00005297347,0.00004038414,0.00007020598,0.000146014,0.000007515576,0.00003598939,0.00009566149,6.657139e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001442911,"about_ca_system_score_gemma":0.00003377188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001390631,"about_ca_topic_score_gemma":0.00001283128,"domain_scores_codex":[0.9991875,0.0001499577,0.0004225401,0.00007617545,0.00006547084,0.00009829853],"domain_scores_gemma":[0.9993072,0.00008120594,0.0003806834,0.00007645831,0.0001231827,0.00003131589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001603305,0.0000431634,0.001032806,0.000007120597,0.00001324617,0.000001318429,0.0001587479,0.0001027919,0.9931551,0.0002383863,0.00001340524,0.005073645],"study_design_scores_gemma":[0.001207731,0.001093774,0.02904871,0.0000213521,0.00003066249,0.00008168862,0.00102892,0.0001052961,0.9609877,0.002917555,0.003356839,0.0001197012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962218,0.0009137742,0.00077333,0.00033012,0.00006698116,0.00004838134,0.000001417602,0.0000012139,0.001642913],"genre_scores_gemma":[0.997946,0.00139925,0.0001934534,0.0001035805,0.0001101703,8.452489e-7,0.000007246965,0.000005020514,0.0002343967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03216727,"threshold_uncertainty_score":0.2160195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183315831600973,"score_gpt":0.270490774207689,"score_spread":0.2586576158916793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}