{"id":"W2020974878","doi":"10.1007/s10456-014-9422-9","title":"Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer","year":2014,"lang":"en","type":"article","venue":"Angiogenesis","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; National Research Council Canada; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Topotecan; Pazopanib; Medicine; Ovarian cancer; Chemotherapy; Pharmacology; Sunitinib; Cancer; Oncology; Paclitaxel; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005167663,0.0002628969,0.001099249,0.0006165473,0.00003618353,0.00001404121,0.0001584698,0.000134128,0.0002707209],"category_scores_gemma":[0.0001038091,0.000236947,0.000482716,0.001504192,0.00005930676,0.00006169314,0.0000463738,0.00004112019,0.000008219621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006148034,"about_ca_system_score_gemma":0.0002523799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008085888,"about_ca_topic_score_gemma":0.006500317,"domain_scores_codex":[0.997831,0.0001965238,0.0006169556,0.0006806176,0.0002823322,0.0003925099],"domain_scores_gemma":[0.9985402,0.0001845562,0.0001754655,0.0007376951,0.000149323,0.0002127458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02075756,0.000770495,0.8769816,0.00009999534,0.004187927,0.0000530061,0.0007973023,0.00285631,0.004545893,0.00008114921,0.0001451103,0.08872368],"study_design_scores_gemma":[0.004073325,0.0003824994,0.9768894,0.0001665591,0.001932695,6.693596e-7,0.00004160633,0.0002889759,0.01297953,0.0000208297,0.002993978,0.0002298791],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916078,0.001637837,0.000408946,0.00516671,0.0001226374,0.0008624783,0.00007517964,0.00003000465,0.00008836482],"genre_scores_gemma":[0.9944358,0.000241447,0.002814646,0.001169923,0.0000843817,0.0008640849,0.00002752744,0.0000434139,0.0003187859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09990788,"threshold_uncertainty_score":0.9662419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931390447684156,"score_gpt":0.3181504694778853,"score_spread":0.2988365650010437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}