{"id":"W2021082805","doi":"10.1021/mp8000815","title":"Formulation and Delivery of siRNA by Oleic Acid and Stearic Acid Modified Polyethylenimine","year":2008,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Polyethylenimine; Small interfering RNA; Chemistry; Stearic acid; Lipofectamine; Transfection; Oleic acid; Molecular biology; Biophysics; Biochemistry; Biology; Organic chemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008037812,0.0001755055,0.0001669084,0.00005641628,0.00007405785,0.00001159598,0.0001067276,0.0001390069,0.000006429885],"category_scores_gemma":[0.0000178254,0.000180575,0.00005551153,0.00007322467,0.0001147527,0.000009866794,0.0001272639,0.0001003575,0.000001867501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007608908,"about_ca_system_score_gemma":0.00003561415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001570939,"about_ca_topic_score_gemma":0.000002040058,"domain_scores_codex":[0.9990928,0.00004721144,0.0002234291,0.0002855842,0.0001420243,0.0002090003],"domain_scores_gemma":[0.9995039,0.000006404731,0.00009020512,0.0002002303,0.00009250367,0.0001067603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001181274,0.0000470933,0.001076511,0.00002920812,0.00007357956,0.00001174937,0.00008279752,0.00004095566,0.9938182,0.00001559851,0.0004120437,0.004274169],"study_design_scores_gemma":[0.0009068752,0.0002434646,0.000588691,0.000009426008,0.00005408284,0.00006735986,0.00002641566,0.001667441,0.9942124,0.00002683226,0.002003194,0.0001937618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827937,0.01326629,0.003403166,0.00007204847,0.00005071134,0.0001509907,0.00003597015,0.000009298727,0.0002177714],"genre_scores_gemma":[0.9946167,0.004256268,0.000383559,0.0004349015,0.00003439077,0.00000658413,0.00009586405,0.00002156534,0.0001501544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182296,"threshold_uncertainty_score":0.7363635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605592611318934,"score_gpt":0.2734468955386549,"score_spread":0.2473909694254655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}