{"id":"W2021082805","doi":"10.1021/mp8000815","title":"Formulation and Delivery of siRNA by Oleic Acid and Stearic Acid Modified Polyethylenimine","year":2008,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Polyethylenimine; Small interfering RNA; Chemistry; Stearic acid; Lipofectamine; Transfection; Oleic acid; Molecular biology; Biophysics; Biochemistry; Biology; Organic chemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605499,0.0003306542,0.0002743152,0.0002150505,0.0001268036,0.0002956472,0.0002703853,0.000411884,0.0006685156],"category_scores_gemma":[0.0001690949,0.0001968508,0.0002938238,0.0001322915,0.0001459859,0.0003403534,0.0001863437,0.000356226,0.0004453752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003038424,"about_ca_system_score_gemma":0.0002238377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003093427,"about_ca_topic_score_gemma":0.0004303575,"domain_scores_codex":[0.9998386,0.00002737831,0.00002347781,0.00003857037,0.00005178567,0.00002018242],"domain_scores_gemma":[0.9999166,0.0000164342,0.00002708061,0.000007795675,0.00001863041,0.00001358831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002216094,0.00001260522,0.00002175979,0.00003058677,0.000002526262,0.00002327502,0.000007065872,0.00005916673,0.9987317,0.00003620044,0.000006883246,0.001046077],"study_design_scores_gemma":[0.000009767326,0.0003267055,0.0003685523,0.000003701755,0.000009604661,0.0001066496,0.000004930632,0.0006615942,0.9965906,0.00001563195,0.0018979,0.000004308974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599587,0.00514961,0.03232336,0.0001008377,0.00006226954,0.0002495615,0.0001566939,0.0001396859,0.00185925],"genre_scores_gemma":[0.9422299,0.004043251,0.04196882,0.0001170673,0.00003782524,0.0003156003,0.0004996755,0.00008572263,0.01070215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006685156,"threshold_uncertainty_score":0.002236426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605592611318934,"score_gpt":0.2734468955386549,"score_spread":0.2473909694254655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}