{"id":"W2021086919","doi":"10.1002/cbic.200600006","title":"Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6","year":2006,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"University of Arizona; Vanderbilt University","keywords":"Cofactor; Hydrogen peroxide; Chemistry; Natural product; Dioxygenase; Organic synthesis; Cumene hydroperoxide; Cumene; Enzyme; Stereochemistry; Biochemistry; Organic chemistry; Combinatorial chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005787344,0.0003354125,0.0004705166,0.0001089375,0.0001162716,0.00001646761,0.0002251816,0.0003251685,0.00009426263],"category_scores_gemma":[0.0002411689,0.000301009,0.00008714877,0.0003704631,0.0001794759,0.00008300809,0.0001064473,0.0004538524,0.000002485498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000106281,"about_ca_system_score_gemma":0.0001485419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001470015,"about_ca_topic_score_gemma":0.0001433525,"domain_scores_codex":[0.9980628,0.0001361138,0.0005549308,0.0005597614,0.0001325641,0.0005538297],"domain_scores_gemma":[0.9987778,0.0003798462,0.0002945734,0.0002209301,0.0001639224,0.0001629322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003237644,0.0004338364,0.002230731,0.00009687329,0.0001193813,0.000002778896,0.0002922711,0.000009629769,0.9881874,0.00001092736,0.003766584,0.001611957],"study_design_scores_gemma":[0.007041805,0.0001509984,0.003037045,0.0000111351,0.000136034,0.000008185993,0.00007307217,0.00168587,0.9762095,0.00004652631,0.01126169,0.0003381433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955605,0.002266312,0.00001902406,0.0003443111,0.0002874836,0.0008235119,0.000402834,0.00005204506,0.0002440398],"genre_scores_gemma":[0.9974275,0.0003661961,0.0001992513,0.0002218805,0.0001265365,0.00008614817,0.0001724085,0.0000411821,0.001358873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01197789,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03592656775043462,"score_gpt":0.3605924039907372,"score_spread":0.3246658362403025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}