{"id":"W2021086919","doi":"10.1002/cbic.200600006","title":"Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6","year":2006,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"University of Arizona; Vanderbilt University","keywords":"Cofactor; Hydrogen peroxide; Chemistry; Natural product; Dioxygenase; Organic synthesis; Cumene hydroperoxide; Cumene; Enzyme; Stereochemistry; Biochemistry; Organic chemistry; Combinatorial chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003171388,0.0003548776,0.0002988509,0.0001300788,0.0001114794,0.0002881465,0.0002428348,0.0001944242,0.002280139],"category_scores_gemma":[0.0004939283,0.0001300153,0.0002114083,0.0002129328,0.0002062545,0.0001929006,0.0001753985,0.0003881516,0.001015215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002520694,"about_ca_system_score_gemma":0.0002192256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003545214,"about_ca_topic_score_gemma":0.0005643758,"domain_scores_codex":[0.9997645,0.000054818,0.00002005764,0.00006951461,0.00006277774,0.00002831774],"domain_scores_gemma":[0.9997039,0.00005712896,0.0000930536,0.00006913633,0.00003242061,0.00004426658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001361041,0.00002819322,0.0004503741,0.00004548469,0.00001061738,0.00005533768,0.00000840601,0.00005985205,0.994702,0.0001409529,0.0001103048,0.004252265],"study_design_scores_gemma":[0.00001067399,0.0001284312,0.0009146416,0.000001417773,0.00000928893,0.0002266306,0.000004964208,0.0001511675,0.9950722,0.00004337672,0.00343402,0.000003144466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698074,0.002496426,0.0222381,0.0002338382,0.0001074302,0.00005107825,0.0008847222,0.0004295996,0.003751451],"genre_scores_gemma":[0.9827358,0.001151471,0.01172077,0.00004714012,0.00001613798,0.00002381893,0.001375006,0.00007845743,0.002851487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002280139,"threshold_uncertainty_score":0.007627845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03592656775043462,"score_gpt":0.3605924039907372,"score_spread":0.3246658362403025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}