{"id":"W2021120315","doi":"10.1210/en.2005-1487","title":"Coding<i>GNAS</i>Mutations Leading to Hormone Resistance Impair<i>in Vitro</i>Agonist- and Cholera Toxin-Induced Adenosine Cyclic 3′,5′-Monophosphate Formation Mediated by Human XLαs","year":2006,"lang":"en","type":"article","venue":"Endocrinology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; Royal Victoria Regional Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Public Health Service","keywords":"GNAS complex locus; Gs alpha subunit; Cholera toxin; G protein-coupled receptor; Endocrinology; Internal medicine; Biology; Receptor; Pseudohypoparathyroidism; Signal transduction; Wild type; G protein; Cell biology; Mutant; Parathyroid hormone; Biochemistry; Medicine; Calcium; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009867195,0.0002277762,0.0002635894,0.0001281233,0.0001901059,0.00004598523,0.0001709121,0.0001302494,0.000007343631],"category_scores_gemma":[0.00006126024,0.0002542553,0.00004908621,0.0001873862,0.00006603514,0.00001456909,0.0001290814,0.0001455447,0.00002082423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004395999,"about_ca_system_score_gemma":0.00002177669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000202328,"about_ca_topic_score_gemma":0.0001955463,"domain_scores_codex":[0.9983334,0.00005945578,0.0004450314,0.0004665471,0.000105583,0.0005899807],"domain_scores_gemma":[0.9994223,0.00002386217,0.0001357431,0.0002697584,0.00005206373,0.00009623317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002892089,0.0000481444,0.0006844676,0.00001523133,0.00001355296,0.000007698534,0.0001035248,0.00002171012,0.9966745,0.00009083695,0.00169161,0.0006197494],"study_design_scores_gemma":[0.001523291,0.0002587427,0.03563508,0.00001605175,0.00001839579,0.00006965165,0.0001011649,0.0000452164,0.9434608,0.00009521157,0.01844707,0.0003293183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947593,0.002150247,0.0005418507,0.001187032,0.00009940359,0.000315332,0.00003443657,0.00003506055,0.0008773064],"genre_scores_gemma":[0.9971222,0.0001589787,0.0008702361,0.0004080003,0.00007694639,0.00007696408,0.0004470762,0.00003151087,0.0008080333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05321374,"threshold_uncertainty_score":0.9999909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008624274444104416,"score_gpt":0.2448305225797903,"score_spread":0.2362062481356859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}