{"id":"W2021120315","doi":"10.1210/en.2005-1487","title":"Coding<i>GNAS</i>Mutations Leading to Hormone Resistance Impair<i>in Vitro</i>Agonist- and Cholera Toxin-Induced Adenosine Cyclic 3′,5′-Monophosphate Formation Mediated by Human XLαs","year":2006,"lang":"en","type":"article","venue":"Endocrinology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; Royal Victoria Regional Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Public Health Service","keywords":"GNAS complex locus; Gs alpha subunit; Cholera toxin; G protein-coupled receptor; Endocrinology; Internal medicine; Biology; Receptor; Pseudohypoparathyroidism; Signal transduction; Wild type; G protein; Cell biology; Mutant; Parathyroid hormone; Biochemistry; Medicine; Calcium; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008815712,0.0004581633,0.0001187817,0.0001325409,0.0001028159,0.0002330767,0.0001794388,0.0002046411,0.002023738],"category_scores_gemma":[0.000108771,0.0001235251,0.0002418714,0.0001311661,0.0003044466,0.0001129379,0.0001739112,0.0004191713,0.0006838904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993297,"about_ca_system_score_gemma":0.0001569614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028379,"about_ca_topic_score_gemma":0.001089088,"domain_scores_codex":[0.999886,0.00001884943,0.00001628108,0.0000245073,0.00002855267,0.00002571375],"domain_scores_gemma":[0.9998587,0.00002359422,0.00005294886,0.00002111472,0.000007175861,0.00003651362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006357639,0.00001143701,0.0001491543,0.000007415611,0.000003000724,0.00009447935,0.000007836421,0.00003433489,0.9992219,0.00007791645,0.00001923023,0.000309749],"study_design_scores_gemma":[0.00003334069,0.0001875642,0.005918506,0.000005343965,0.00001322321,0.001142834,0.00004542362,0.0008178782,0.9891917,0.00005109911,0.002588072,0.000005023342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996781,0.0002061122,0.001466454,0.00004946824,0.00001952122,0.0000185313,0.0004636365,0.00005958388,0.0009357377],"genre_scores_gemma":[0.9946429,0.0002527248,0.001478952,0.00004255419,0.000009521294,0.00001904619,0.001302419,0.00003779035,0.002214141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023738,"threshold_uncertainty_score":0.006770015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008624274444104416,"score_gpt":0.2448305225797903,"score_spread":0.2362062481356859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}