{"id":"W2021120349","doi":"10.1074/jbc.m101933200","title":"The Selectivity Filter of the Voltage-gated Sodium Channel Is Involved in Channel Activation","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Max Kade Foundation; National Institutes of Health; Procter and Gamble; Fondation pour la Recherche Médicale; McMaster University; American Heart Association","keywords":"Chemistry; Sodium channel; Biophysics; Depolarization; Gating; Alanine; KcsA potassium channel; Alanine scanning; Selectivity; Aspartic acid; Sodium; Mutant; Amino acid; Ion channel; Biochemistry; Mutagenesis; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004132042,0.000113954,0.0001475373,0.00001760794,0.00009048842,0.00001291846,0.0002237084,0.0002521222,0.00002938992],"category_scores_gemma":[0.0003455335,0.00005961833,0.0001551927,0.0001927433,0.0001159329,0.000007170842,0.00006836979,0.0002272435,6.565053e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003179541,"about_ca_system_score_gemma":0.00005475098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004634439,"about_ca_topic_score_gemma":0.000003086478,"domain_scores_codex":[0.9991307,0.00006464174,0.0003496544,0.0001402904,0.0001512231,0.0001635029],"domain_scores_gemma":[0.9991432,0.00004071078,0.000379759,0.0001615912,0.0002312196,0.00004353203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004598337,0.0001044598,0.004366177,0.000009147703,0.00003076597,9.912094e-7,0.00004152951,0.0001567531,0.9924164,0.000002377679,0.001862314,0.0005492382],"study_design_scores_gemma":[0.0005505718,0.0001249391,0.01423358,0.00002539331,0.000005353872,0.00002769712,0.0001645777,0.0006167878,0.9760271,0.0003049353,0.007833823,0.00008526992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971584,0.0001459892,0.000958494,0.001119924,0.0002135406,0.00007838877,0.000003617723,0.000003067845,0.0003185611],"genre_scores_gemma":[0.9984822,0.0002496235,0.000008882083,0.0002438478,0.0004605849,0.000002994522,0.00001069519,0.000005851864,0.0005353235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01638934,"threshold_uncertainty_score":0.2431165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644791454818375,"score_gpt":0.2453320885944605,"score_spread":0.2188841740462767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}