{"id":"W2021120349","doi":"10.1074/jbc.m101933200","title":"The Selectivity Filter of the Voltage-gated Sodium Channel Is Involved in Channel Activation","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Max Kade Foundation; National Institutes of Health; Procter and Gamble; Fondation pour la Recherche Médicale; McMaster University; American Heart Association","keywords":"Chemistry; Sodium channel; Biophysics; Depolarization; Gating; Alanine; KcsA potassium channel; Alanine scanning; Selectivity; Aspartic acid; Sodium; Mutant; Amino acid; Ion channel; Biochemistry; Mutagenesis; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153437,0.0002374776,0.0002884342,0.0001545481,0.0001470269,0.0003731285,0.0001763332,0.0002432909,0.0006682417],"category_scores_gemma":[0.0002155181,0.0001133583,0.0001919019,0.00009775595,0.0003117705,0.000302451,0.0001892202,0.000215158,0.0003936463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967731,"about_ca_system_score_gemma":0.0002134524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003926919,"about_ca_topic_score_gemma":0.000290095,"domain_scores_codex":[0.9998951,0.00001201084,0.000007560032,0.00003423145,0.00002867157,0.00002240269],"domain_scores_gemma":[0.9998548,0.00003115405,0.00004642847,0.00001178962,0.00002093867,0.00003471335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007025284,0.000003516772,0.0003664826,0.00001098677,0.000001660846,0.00003212994,0.000006105999,0.00003285558,0.9978005,0.000128752,0.0000111654,0.001535491],"study_design_scores_gemma":[0.00002947355,0.0003437318,0.03599176,0.000005850657,0.00001503094,0.0009789423,0.0000295545,0.002001626,0.9576721,0.0004875249,0.002431985,0.00001238935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991194,0.001279117,0.006524151,0.00009515423,0.00001581697,0.00001179636,0.00009364247,0.0001180112,0.0006684057],"genre_scores_gemma":[0.9966948,0.0004094558,0.002086531,0.00002715612,0.000009350484,0.000007288271,0.00009357625,0.00001164701,0.0006601513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006682417,"threshold_uncertainty_score":0.002235472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02644791454818375,"score_gpt":0.2453320885944605,"score_spread":0.2188841740462767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}