{"id":"W2021135844","doi":"10.1523/jneurosci.3600-11.2011","title":"Plasticity of Prefrontal Attention Circuitry: Upregulated Muscarinic Excitability in Response to Decreased Nicotinic Signaling Following Deletion of α5 or β2 Subunits","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Nicotinic agonist; Neuroscience; Muscarinic acetylcholine receptor; Cholinergic; Prefrontal cortex; Acetylcholine receptor; Nicotinic Antagonist; Alpha-4 beta-2 nicotinic receptor; Acetylcholine; Biology; Nicotinic acetylcholine receptor; Chemistry; Receptor; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001502882,0.0001390368,0.0003216395,0.0001760902,0.00004106264,0.000007493477,0.000414811,0.00009574902,0.00000980843],"category_scores_gemma":[0.003379147,0.0001201589,0.0001822813,0.0004885436,0.0001133094,0.00003295708,0.0001368415,0.0001664244,4.306349e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004229487,"about_ca_system_score_gemma":0.0003231172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003344746,"about_ca_topic_score_gemma":0.00003458242,"domain_scores_codex":[0.9978202,0.0004161364,0.00086095,0.0002947169,0.000371854,0.0002361368],"domain_scores_gemma":[0.9986809,0.0001105168,0.0006187093,0.0002236475,0.0002291767,0.0001370331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002265021,0.0003674559,0.03788021,0.00001558526,0.000009842091,0.000003233978,0.0001909732,0.000142476,0.958793,7.381677e-7,0.000003023597,0.0003284781],"study_design_scores_gemma":[0.001113217,0.002125665,0.5412561,0.000111551,0.00003115565,0.00004253445,0.0001395429,0.0001668546,0.4548745,0.000009169538,0.00001915021,0.0001105732],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961234,0.00002972033,0.003260048,0.00001447925,0.0003309057,0.000213043,0.000005904605,0.000003360424,0.00001915693],"genre_scores_gemma":[0.9992286,0.0000105517,0.0006595624,0.00003062145,0.00002988073,0.000002336367,9.907041e-7,0.00001235434,0.00002512668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5039185,"threshold_uncertainty_score":0.4899936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03654938714386048,"score_gpt":0.2835539574294849,"score_spread":0.2470045702856244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}