{"id":"W2021142247","doi":"10.1016/j.ymgme.2011.09.027","title":"Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity","year":2011,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Proprotein convertase; Single-nucleotide polymorphism; Biosynthesis; PCSK9; Biology; Genetics; Gene; Molecular biology; Chemistry; Biochemistry; Genotype; LDL receptor; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007353012,0.001434108,0.000931151,0.0008754014,0.0004414751,0.0006448937,0.000496421,0.001123116,0.006533116],"category_scores_gemma":[0.002334603,0.0005873996,0.001755447,0.0006855694,0.0006778736,0.0003193339,0.0005610524,0.0008342265,0.0005562514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002662902,"about_ca_system_score_gemma":0.0002761645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004818491,"about_ca_topic_score_gemma":0.003178009,"domain_scores_codex":[0.9986871,0.0003775707,0.0001878494,0.0004405781,0.000144365,0.0001624342],"domain_scores_gemma":[0.9985061,0.0007429127,0.0002945199,0.0001480037,0.00006696629,0.0002415333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.138918,0.0006474259,0.2094003,0.0002323621,0.005091459,0.004911424,0.001133275,0.001544683,0.62281,0.0009583883,0.000847589,0.01350502],"study_design_scores_gemma":[0.001269584,0.002568329,0.9657125,0.00002106547,0.002786502,0.003084562,0.000239609,0.002612178,0.01986578,0.0006469265,0.00111568,0.00007729715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998742,0.0001938796,0.000311654,0.00006044795,0.00001989019,0.000009905495,0.0003852744,0.00001889838,0.000258056],"genre_scores_gemma":[0.9984733,0.00004093468,0.0003197126,0.00003849075,0.00001882483,0.00001613322,0.0002870611,0.00002421352,0.0007812954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006533116,"threshold_uncertainty_score":0.02185547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00857354313743037,"score_gpt":0.1828172314272642,"score_spread":0.1742436882898338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}