{"id":"W2021144570","doi":"10.1158/1535-7163.targ-13-c77","title":"Abstract C77: A novel BRCA2 targeting antisense oligonucleotide sensitizes human tumor cells to chemotherapy and radiotherapy - the induction of ‘complementary lethality’ by targeting DNA repair.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Cisplatin; RAD51; Carboplatin; Cancer research; Synthetic lethality; DNA repair; Cancer; Biology; Cancer cell; Homologous recombination; DNA damage; Population; Molecular biology; Medicine; Chemotherapy; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001228407,0.0004776393,0.0002901761,0.000290987,0.0001304615,0.0001524065,0.0002389626,0.0004020945,0.002196396],"category_scores_gemma":[0.0001080194,0.000118509,0.0002161257,0.0001152693,0.0001845757,0.0001017721,0.0001148496,0.0003933783,0.000505599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331215,"about_ca_system_score_gemma":0.0003289701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029133,"about_ca_topic_score_gemma":0.001369412,"domain_scores_codex":[0.999859,0.0000162108,0.00001498591,0.00003810242,0.00004646167,0.0000252346],"domain_scores_gemma":[0.9999231,0.00001506314,0.00001503087,0.000007979599,0.0000158576,0.00002299055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007956577,0.0000599086,0.00005287319,0.00004251402,0.000005820254,0.00003855009,0.000008649637,0.00006602352,0.997343,0.00008757428,0.0001456155,0.002069973],"study_design_scores_gemma":[0.00005539212,0.001147407,0.0009796028,0.000006648193,0.00002270965,0.0002203789,0.000008108419,0.0006150787,0.9932309,0.00001867226,0.003689682,0.000005383162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843441,0.003076225,0.005919964,0.0002473427,0.0002104816,0.0002376933,0.0007641152,0.000269624,0.004930448],"genre_scores_gemma":[0.9838017,0.001627772,0.00666279,0.0002457582,0.0000430444,0.0001890996,0.001847418,0.00004859268,0.005533923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002196396,"threshold_uncertainty_score":0.007347703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380775929550519,"score_gpt":0.267652551183321,"score_spread":0.2538447918878158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}