{"id":"W2021191515","doi":"10.1089/adt.2008.142","title":"Quantitative Optimization of Reverse Transfection Conditions for 384-Well siRNA Library Screening","year":2008,"lang":"en","type":"article","venue":"Assay and Drug Development Technologies","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Transfection; Small interfering RNA; Chemistry; Molecular biology; Computational biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006465082,0.003235436,0.00320619,0.001995379,0.001379694,0.001623371,0.002566587,0.001348639,0.00768148],"category_scores_gemma":[0.005057639,0.001680949,0.00137151,0.001812071,0.00121717,0.0009203697,0.001004353,0.003122951,0.008073512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001294947,"about_ca_system_score_gemma":0.001904094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001612613,"about_ca_topic_score_gemma":0.004543297,"domain_scores_codex":[0.988303,0.003810011,0.001484782,0.001554881,0.003992103,0.0008551796],"domain_scores_gemma":[0.9961913,0.001488408,0.0003328392,0.0005786592,0.001255817,0.0001529998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001028916,0.0001083661,0.0001368381,0.0001982866,0.0000176122,0.00004578573,0.0001167781,0.0002728199,0.9936422,0.0003236238,0.0006167896,0.004418065],"study_design_scores_gemma":[0.00001936277,0.0001444672,0.0005132093,0.00001493356,0.00003667843,0.00009820525,0.00002955148,0.001616472,0.9895918,0.0001312936,0.007762303,0.0000417808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1040941,0.003623983,0.8637678,0.0006083456,0.000791345,0.006619535,0.005078114,0.00736816,0.008048651],"genre_scores_gemma":[0.08110829,0.004000983,0.8689744,0.0003777403,0.0001383307,0.01521781,0.01179973,0.002258603,0.01612411],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00768148,"threshold_uncertainty_score":0.03419101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01883699061094318,"score_gpt":0.2416799231473238,"score_spread":0.2228429325363806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}