{"id":"W2021253518","doi":"10.1158/1535-7163.targ-09-a115","title":"Abstract A115: Contextual synthetic lethality: Repair-deficient hypoxic tumor cells are sensitized to poly(ADP-ribose) polymerase (PARP) inhibition","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"PARP1; Poly ADP ribose polymerase; Synthetic lethality; PARP inhibitor; RAD51; Cancer research; Cancer cell; Hypoxia (environmental); Biology; DNA repair; Clonogenic assay; Homologous recombination; Molecular biology; Programmed cell death; DNA damage; Polymerase; Cell culture; Chemistry; Cancer; Apoptosis; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009900808,0.0004307539,0.0003433365,0.0002102897,0.0001757836,0.000276445,0.0002316544,0.0003622254,0.004386676],"category_scores_gemma":[0.0001007794,0.0001359541,0.0003135943,0.0001472281,0.0002378747,0.000149454,0.0002349572,0.0006901576,0.0008101021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001789681,"about_ca_system_score_gemma":0.0001328596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000857008,"about_ca_topic_score_gemma":0.0005580531,"domain_scores_codex":[0.9998604,0.00001861432,0.00001801018,0.00003324634,0.00003853536,0.00003124647],"domain_scores_gemma":[0.9998127,0.00002755572,0.00005029377,0.00003030666,0.00001175317,0.00006743195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008809657,0.00002936974,0.0001411463,0.00002256411,0.00000610614,0.00009978994,0.000009046038,0.000065783,0.9987985,0.0001072018,0.0001076169,0.0005248473],"study_design_scores_gemma":[0.00001871672,0.0006632452,0.007311581,0.000008771663,0.0000176525,0.0007669234,0.00004022386,0.0008863837,0.9871192,0.00007998441,0.003079991,0.000007300384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885012,0.0007523667,0.004996132,0.0001710516,0.00008609484,0.0000510704,0.002853952,0.0002909594,0.002297112],"genre_scores_gemma":[0.9924546,0.0003436954,0.001323121,0.0001049225,0.00001331041,0.00005194139,0.002049948,0.0000838272,0.003574654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004386676,"threshold_uncertainty_score":0.01467484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186838404092943,"score_gpt":0.3087611191718203,"score_spread":0.2768927351308909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}