{"id":"W2021283134","doi":"10.1021/ol9025205","title":"Synthesis and Biological Activity of Oxa-Lacticin A2, a Lantibiotic Analogue with Sulfur Replaced by Oxygen","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Probiotics and Fermented Foods","field":"Agricultural and Biological Sciences","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research","keywords":"Lantibiotics; Chemistry; Sulfur; Peptide; Antimicrobial; Bacteria; Stereochemistry; Combinatorial chemistry; Biological activity; Bacteriocin; Oxygen; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608276,0.0003046693,0.0001831663,0.00011336,0.0001271807,0.0002681996,0.0001621695,0.0002751411,0.0007405483],"category_scores_gemma":[0.0001095301,0.00009399072,0.000181978,0.000143412,0.0001625086,0.0002138812,0.0001287477,0.0003005112,0.0001453509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983245,"about_ca_system_score_gemma":0.0001643714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005551981,"about_ca_topic_score_gemma":0.0005392951,"domain_scores_codex":[0.9999042,0.00002413227,0.000009352873,0.00001990185,0.00002005029,0.00002250968],"domain_scores_gemma":[0.9999336,0.000009761325,0.00001649688,0.000007399599,0.00001104372,0.00002166388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527868,0.00002378288,0.00005088717,0.00001807211,0.000002567118,0.00003378988,0.000007978767,0.0001253441,0.9988428,0.00002812198,0.000007633946,0.0007062435],"study_design_scores_gemma":[0.00003028316,0.0009938353,0.0009994702,0.000002602998,0.00001138176,0.0001508422,0.00001648462,0.0003803034,0.9962934,0.00001642568,0.001099524,0.000005488634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976743,0.0007067202,0.0006753132,0.00003260078,0.000008016195,0.00001453536,0.0001263911,0.00001176453,0.0007505075],"genre_scores_gemma":[0.9966222,0.0003887617,0.001523912,0.00002282464,0.000005478588,0.00001345926,0.0003195568,0.000006260355,0.001097506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007405483,"threshold_uncertainty_score":0.002477407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147612943824406,"score_gpt":0.1902601284040828,"score_spread":0.1787839989658387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}