{"id":"W2021314470","doi":"10.1139/bcb-2012-0058","title":"XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair","year":2012,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; U.S. Bureau of Land Management; Alberta Innovates; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Badan Riset dan Inovasi Nasional","keywords":"DNA repair protein XRCC4; DNA; Non-homologous end joining; DNA repair; DNA ligase; Biology; Cell biology; Biophysics; Chemistry; Genetics; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002204005,0.0004410367,0.0002160732,0.0002920414,0.0003781956,0.0004010421,0.0003702071,0.000640533,0.001368205],"category_scores_gemma":[0.0002253783,0.0002383885,0.0002577625,0.0001861368,0.0002850411,0.0005220837,0.0003779248,0.000325043,0.0008176667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004940809,"about_ca_system_score_gemma":0.0001892284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004977325,"about_ca_topic_score_gemma":0.0004333957,"domain_scores_codex":[0.999848,0.00002262622,0.000009180507,0.00004165863,0.00004020249,0.00003831305],"domain_scores_gemma":[0.9998649,0.000006831916,0.00006788315,0.000009569567,0.00001943732,0.00003122713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00014214,0.00003738896,0.003153022,0.0002119062,0.00003874741,0.0004055485,0.00004839369,0.0006007848,0.9828471,0.001763917,0.0004694509,0.01028152],"study_design_scores_gemma":[0.00004609093,0.000443817,0.03666678,0.00004420996,0.00004831656,0.002415249,0.000155557,0.003303754,0.9000506,0.0009942742,0.05579754,0.0000338942],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9435929,0.02495572,0.02234765,0.0008349785,0.0001748846,0.00007569395,0.0006398416,0.0005201136,0.00685821],"genre_scores_gemma":[0.9834193,0.003362225,0.006863552,0.0001155319,0.00003868396,0.00002652987,0.0007829184,0.00002351834,0.005367758],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001368205,"threshold_uncertainty_score":0.004577041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04121117060546649,"score_gpt":0.2746914831543021,"score_spread":0.2334803125488357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}