{"id":"W2021316249","doi":"10.1158/0008-5472.can-03-2664","title":"Silencing Expression of the Clusterin/Apolipoprotein J Gene in Human Cancer Cells Using Small Interfering RNA Induces Spontaneous Apoptosis, Reduced Growth Ability, and Cell Sensitization to Genotoxic and Oxidative Stress","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"European Commission","keywords":"Clusterin; Gene silencing; Small interfering RNA; Oxidative stress; RNA interference; Apoptosis; Cancer research; Gene expression; Sensitization; Gene; Cancer; Biology; Molecular biology; Cell biology; Chemistry; RNA; Immunology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004406835,0.0001714963,0.0003126321,0.0002998302,0.0001637489,0.00003009796,0.0001598211,0.000119606,0.00002660492],"category_scores_gemma":[0.0001301346,0.0001441852,0.0000301522,0.0004008335,0.000270095,0.00006409381,0.0007272816,0.0003974054,3.57357e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008212563,"about_ca_system_score_gemma":0.0003100749,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00996301,"about_ca_topic_score_gemma":0.001791166,"domain_scores_codex":[0.9981225,0.0002884247,0.0003369451,0.0005025823,0.0003401484,0.000409412],"domain_scores_gemma":[0.9990466,0.0000924246,0.0000961709,0.0003365139,0.0002440286,0.0001842972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003332746,0.00007249244,0.001529632,0.0007828315,0.00000883713,0.00004489403,0.004905786,0.001983321,0.9899737,0.000002721604,0.000001299536,0.0003612295],"study_design_scores_gemma":[0.0009632341,0.0001611134,0.01032059,0.001930206,0.00001938738,0.00003771939,0.0008319508,0.0001027569,0.9854167,0.0000885347,3.397488e-7,0.0001274937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974738,0.0004952876,0.00006470748,0.0003233718,0.00009364072,0.001458041,0.00004348296,0.00001103887,0.00003658144],"genre_scores_gemma":[0.9989209,0.0001791812,0.0005309182,0.00004725001,0.0001207534,0.0001407731,0.000003118352,0.00003539935,0.00002172257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008790958,"threshold_uncertainty_score":0.9966297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06507516048349106,"score_gpt":0.3680186268848295,"score_spread":0.3029434664013385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}