{"id":"W2021316249","doi":"10.1158/0008-5472.can-03-2664","title":"Silencing Expression of the Clusterin/Apolipoprotein J Gene in Human Cancer Cells Using Small Interfering RNA Induces Spontaneous Apoptosis, Reduced Growth Ability, and Cell Sensitization to Genotoxic and Oxidative Stress","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"European Commission","keywords":"Clusterin; Gene silencing; Small interfering RNA; Oxidative stress; RNA interference; Apoptosis; Cancer research; Gene expression; Sensitization; Gene; Cancer; Biology; Molecular biology; Cell biology; Chemistry; RNA; Immunology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148671,0.0002895976,0.0002845155,0.0001897038,0.0001511729,0.0003068059,0.0001385484,0.000240477,0.000321629],"category_scores_gemma":[0.0001433544,0.0001115468,0.0002269475,0.0002141279,0.0002245247,0.00008716272,0.0001243683,0.00024516,0.0001686338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003263713,"about_ca_system_score_gemma":0.0003350418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301639,"about_ca_topic_score_gemma":0.002016463,"domain_scores_codex":[0.9998527,0.00001791237,0.00001824971,0.00003937335,0.00004630969,0.00002547457],"domain_scores_gemma":[0.9999212,0.00001824945,0.00002374645,0.0000114279,0.00001429822,0.00001105166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006237609,0.00001590658,0.0001587069,0.00002194072,0.000005259117,0.00004226221,0.00001784481,0.00005208424,0.9986076,0.00006344242,0.00002512351,0.0009275413],"study_design_scores_gemma":[0.00000958499,0.000216809,0.001847603,0.000001773948,0.00001610349,0.0001537607,0.00001749637,0.0008893848,0.9951738,0.00001653736,0.001654213,0.000002988014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913027,0.001908876,0.005181431,0.0000587529,0.00003179593,0.0000495376,0.0002231022,0.0001298037,0.001114042],"genre_scores_gemma":[0.9924975,0.001277706,0.003714775,0.00004436598,0.000008036304,0.00006137465,0.0005000973,0.00002216813,0.001873992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301639,"threshold_uncertainty_score":0.002588153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06507516048349106,"score_gpt":0.3680186268848295,"score_spread":0.3029434664013385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}