{"id":"W2021343953","doi":"10.4161/cbt.8.24.9987","title":"Inhibition of mammalian target of rapamycin as a therapeutic strategy in the management of bladder cancer","year":2009,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Everolimus; Apoptosis; Angiogenesis; Cancer research; In vivo; Cell growth; Bladder cancer; In vitro; Cell culture; Cancer; Pharmacology; Medicine; Chemistry; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002980018,0.0001818177,0.0002821323,0.00006683735,0.00002221917,0.000003313394,0.0003005714,0.0001916702,0.0002384253],"category_scores_gemma":[0.000001926432,0.0001329513,0.0001145678,0.0002115609,0.0002300618,0.000004361184,0.00001940904,0.0001020377,7.531292e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002661726,"about_ca_system_score_gemma":0.0001287573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002496709,"about_ca_topic_score_gemma":0.00006528692,"domain_scores_codex":[0.9987915,0.0001670087,0.000386068,0.000301739,0.0001133608,0.0002402953],"domain_scores_gemma":[0.9992543,0.00001316384,0.0002373324,0.0003716046,0.0001001765,0.00002336446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005814716,0.0001553301,0.005063029,0.00003519292,0.0002951693,0.000001836775,0.0003089298,0.0006673324,0.9635667,0.0006175897,0.0001935927,0.02851385],"study_design_scores_gemma":[0.001748287,0.001504347,0.02535007,0.00008763294,0.00003921331,0.000002317195,0.0003195039,0.00001197893,0.9633448,0.002780454,0.004623878,0.0001874817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714176,0.02653146,0.0001733477,0.0004360597,0.0001193261,0.0003875761,0.00007093193,0.000004434602,0.0008592427],"genre_scores_gemma":[0.9882717,0.01015038,0.0001036246,0.001118212,0.0001048637,0.0001057884,0.00004464342,0.0000142318,0.00008655499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02832637,"threshold_uncertainty_score":0.5421599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374667315045228,"score_gpt":0.3232176874424791,"score_spread":0.2994710142920268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}