{"id":"W2021346518","doi":"10.1073/pnas.0700923104","title":"β-Catenin directly regulates <i>Islet1</i> expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":245,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"National Heart, Lung, and Blood Institute; University of California, San Francisco; National Institutes of Health; Università degli Studi di Padova; Harvard University; University of Pennsylvania; American Heart Association","keywords":"Progenitor cell; Biology; Embryonic stem cell; Homeobox; Cell biology; Progenitor; Catenin; Transcription factor; Wnt signaling pathway; Stem cell; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007966306,0.0002229606,0.0001192826,0.0002633207,0.0002015436,0.0004236474,0.0001057278,0.0001403771,0.0009190399],"category_scores_gemma":[0.0001162089,0.0001880399,0.0001089558,0.00009470434,0.0002167076,0.000189801,0.0002152289,0.0003855233,0.0003082135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005967916,"about_ca_system_score_gemma":0.0002446724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105997,"about_ca_topic_score_gemma":0.002012513,"domain_scores_codex":[0.9998989,0.000007933447,0.000007177025,0.00002636029,0.00003894083,0.00002066074],"domain_scores_gemma":[0.9999166,0.00001267098,0.00002730373,0.000006379097,0.000009895415,0.00002722235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000147231,0.00000381763,0.0005217475,0.000008595331,0.000001032349,0.00004035878,0.000008234796,0.00002324223,0.9986095,0.00006362468,0.00001476991,0.0006902282],"study_design_scores_gemma":[0.000007880788,0.00004709589,0.02460265,0.00000693903,0.00000787212,0.0004135557,0.00003339593,0.0005838997,0.9721279,0.00007537683,0.00209004,0.000003338483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942544,0.001504444,0.00141295,0.00007207215,0.00001002356,0.000007881661,0.0001906542,0.00006708624,0.002480352],"genre_scores_gemma":[0.9956584,0.0006366502,0.0006613108,0.00002765513,0.000003928909,0.000007307278,0.0003897455,0.00001542879,0.002599761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105997,"threshold_uncertainty_score":0.004330039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03065558357585464,"score_gpt":0.3058940407154672,"score_spread":0.2752384571396126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}