{"id":"W2021348305","doi":"10.1186/1471-2156-11-39","title":"How old is this mutation? - a study of three Ashkenazi Jewish founder mutations","year":2010,"lang":"en","type":"article","venue":"BMC Genetics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McGill University Health Centre; Western University; Actua; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"Mitacs; Ontario Genomics; Ontario Genomics Institute; Genome Canada","keywords":"Founder effect; Judaism; Genetics; Mutation; Genealogy; History; Biology; Haplotype; Gene; Genotype; Archaeology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009363142,0.0001612524,0.000151608,0.00005241286,0.00008761592,0.00007353829,0.0002372561,0.0001483112,0.00004935641],"category_scores_gemma":[0.0001451401,0.0001698458,0.0000860213,0.0001130282,0.00008680998,0.000003105686,0.000123512,0.0001104197,0.00000859298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000867538,"about_ca_system_score_gemma":0.0001639312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006378234,"about_ca_topic_score_gemma":0.005415274,"domain_scores_codex":[0.9990251,0.00002080294,0.0002327527,0.0003343927,0.0001863121,0.0002006575],"domain_scores_gemma":[0.9988623,0.00004326366,0.0001387628,0.0006145411,0.0002528081,0.00008829893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025521,0.001788513,0.4158284,0.00009323752,0.0003904127,0.0000110373,0.00196063,0.001603499,0.5564472,0.0009892923,0.009880996,0.01090418],"study_design_scores_gemma":[0.00939478,0.005371582,0.4011552,0.00002465917,0.0008120153,0.00008476981,0.003532587,0.003965111,0.4839796,0.01027322,0.07948276,0.001923701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940266,0.0004469623,0.003951644,0.0001295701,0.0004277443,0.0004314284,0.00008264133,0.000008916511,0.0004945175],"genre_scores_gemma":[0.9925208,0.0000583354,0.006007235,0.0001861123,0.000299374,0.00004620863,0.00007605718,0.00003405958,0.0007718306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07246757,"threshold_uncertainty_score":0.6926111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993075267995886,"score_gpt":0.2647984794280124,"score_spread":0.2448677267480535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}