{"id":"W2021379342","doi":"10.1002/gcc.20653","title":"RET‐mediated gene expression pattern is affected by isoform but not oncogenic mutation","year":2009,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Gene isoform; Gene; Multiple endocrine neoplasia type 2; Microarray analysis techniques; Genetics; Gene expression; Mutant; Microarray; Mutation; Receptor tyrosine kinase; Proto-Oncogene Proteins c-ret; Cancer research; Receptor; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006164905,0.0002613098,0.0003493261,0.00008356982,0.0001109674,0.00002870009,0.00007406741,0.0002267992,0.000543229],"category_scores_gemma":[0.00001324205,0.0002280767,0.0001075258,0.0002181141,0.00004910601,0.00009267939,0.00003172064,0.0001838417,0.00002745217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004962,"about_ca_system_score_gemma":0.0001459308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001796918,"about_ca_topic_score_gemma":0.00002000513,"domain_scores_codex":[0.9985039,0.00002742938,0.0002800685,0.0004714521,0.0003517127,0.0003654076],"domain_scores_gemma":[0.9992314,0.00001626711,0.0001349023,0.0003019189,0.00009848127,0.0002170096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006123,0.00006544323,0.0002186988,0.00004837717,0.00005545927,0.00005143551,0.0003463975,0.000006551645,0.8106024,4.102293e-7,0.00541763,0.1830865],"study_design_scores_gemma":[0.002831383,0.0005114815,0.007370643,0.0002182564,0.0001535847,0.0001154757,0.00006173801,0.0005031699,0.9751968,0.0000109744,0.012737,0.0002895425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686756,0.02814725,0.0004629436,0.001430273,0.0002891523,0.0004761813,0.0002741783,0.0001228495,0.0001216221],"genre_scores_gemma":[0.982978,0.0116808,0.0001244667,0.003699498,0.0003328265,0.0000745822,0.0004065363,0.00004308339,0.0006602361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.182797,"threshold_uncertainty_score":0.9300699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00950292938840649,"score_gpt":0.2522874092396558,"score_spread":0.2427844798512493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}