{"id":"W2021379342","doi":"10.1002/gcc.20653","title":"RET‐mediated gene expression pattern is affected by isoform but not oncogenic mutation","year":2009,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Gene isoform; Gene; Multiple endocrine neoplasia type 2; Microarray analysis techniques; Genetics; Gene expression; Mutant; Microarray; Mutation; Receptor tyrosine kinase; Proto-Oncogene Proteins c-ret; Cancer research; Receptor; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008451047,0.0001908374,0.0001384994,0.0002616883,0.0001070748,0.0001936499,0.00008313574,0.0001899006,0.001314577],"category_scores_gemma":[0.000119397,0.0001423338,0.0001942083,0.0001760663,0.0001851011,0.0001421435,0.0001154524,0.0001726884,0.0002945148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697738,"about_ca_system_score_gemma":0.0001082667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005441479,"about_ca_topic_score_gemma":0.001007508,"domain_scores_codex":[0.9998395,0.00001751829,0.00001072977,0.0000624006,0.00003785921,0.00003192617],"domain_scores_gemma":[0.9998939,0.00001675982,0.00003946019,0.00001239517,0.00001291434,0.00002460238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009920425,0.000005815541,0.0009996435,0.000007406464,0.000003271314,0.00005002991,0.00001239831,0.00001262814,0.9983637,0.00001981132,0.00001717397,0.0004088996],"study_design_scores_gemma":[0.0000256283,0.000498019,0.3270898,0.000008526436,0.00003917626,0.002403175,0.0001896343,0.0007760996,0.6662405,0.0001176966,0.002596364,0.0000152517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983999,0.0002548523,0.0003031788,0.0000251495,0.000007814017,0.000004331126,0.0003675052,0.00001398358,0.0006233185],"genre_scores_gemma":[0.9960362,0.0002538318,0.0005264942,0.0000343334,0.000005767328,0.00001355361,0.000880548,0.000009673297,0.002239498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314577,"threshold_uncertainty_score":0.00439769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00950292938840649,"score_gpt":0.2522874092396558,"score_spread":0.2427844798512493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}