{"id":"W2021405109","doi":"10.1016/j.biologicals.2013.11.011","title":"Report on the international workshop on alternatives to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: State of the science and the path forward","year":2014,"lang":"en","type":"article","venue":"Biologicals","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada); Health Canada","funders":"National Institutes of Health; U.S. Food and Drug Administration; Henan Institute of Science and Technology; National Institute of Environmental Health Sciences; University of Virginia","keywords":"Test (biology); Medicine; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001534563,0.0001124398,0.0001582246,0.00003669082,0.0004795578,0.00003639922,0.000373837,0.00004885794,0.00005279907],"category_scores_gemma":[0.00606066,0.00003495098,0.00006488478,0.0001594705,0.0003859413,0.00002630226,0.000169058,0.00009814744,0.00000862818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002683366,"about_ca_system_score_gemma":0.00002080005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003096636,"about_ca_topic_score_gemma":0.00001787338,"domain_scores_codex":[0.9991479,0.0001827071,0.0002450812,0.0002393722,0.00003995727,0.000145004],"domain_scores_gemma":[0.9970974,0.002099606,0.000206656,0.0003471925,0.0002381663,0.00001100613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008601824,0.0002289059,0.004806678,0.000007852327,0.0001329998,5.000019e-7,0.000517794,0.0001287496,0.9444718,0.02461419,0.007389145,0.01684115],"study_design_scores_gemma":[0.002930299,0.001309496,0.2161994,0.0001692593,0.00008682645,0.000119262,0.0003430647,0.0009434429,0.2609819,0.004327151,0.5122218,0.0003681709],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623226,0.00008215293,0.0005709869,0.03519327,0.0007945013,0.0006211504,0.00004239903,0.00001393439,0.0003590275],"genre_scores_gemma":[0.9967047,0.00007796728,0.000019616,0.000978004,0.000109078,0.00007421154,0.00001570499,0.000004603485,0.002016108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.68349,"threshold_uncertainty_score":0.7255614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899204152976533,"score_gpt":0.256287146343748,"score_spread":0.2372951048139827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}