{"id":"W2021422325","doi":"10.1099/mic.0.030064-0","title":"Overcoming codon-usage bias in heterologous protein expression in Streptococcus gordonii","year":2009,"lang":"en","type":"article","venue":"Microbiology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Streptococcus gordonii; Biology; Heterologous; Gene; Codon usage bias; Stop codon; Transfer RNA; Genetics; Heterologous expression; Microbiology; Molecular biology; Recombinant DNA; Streptococcus; Bacteria; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003179962,0.00035458,0.0004013553,0.0002238415,0.0001460404,0.000420637,0.0002036391,0.0002930122,0.0003427138],"category_scores_gemma":[0.0003849757,0.0001382503,0.0002783885,0.0002810077,0.0002205452,0.0001720396,0.0003893074,0.0005184685,0.0002280985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552115,"about_ca_system_score_gemma":0.000348575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000911481,"about_ca_topic_score_gemma":0.001561239,"domain_scores_codex":[0.9996508,0.00008363887,0.00004700539,0.00004644332,0.0001180053,0.0000541135],"domain_scores_gemma":[0.9997678,0.00005340745,0.00009094848,0.00003420454,0.0000328966,0.00002075423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002181009,0.000006936691,0.000306493,0.0000210031,0.000003175121,0.0000442502,0.00001181819,0.00004412984,0.998747,0.00003081294,0.000008907635,0.0007536841],"study_design_scores_gemma":[0.000005170569,0.0002117552,0.00564782,0.00001349486,0.00002827398,0.0005889048,0.00009263524,0.001758513,0.9889281,0.00007797917,0.002638327,0.000008998474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951526,0.0005890069,0.003529601,0.00008074113,0.00001844725,0.00001588075,0.00008343851,0.00005054319,0.0004796218],"genre_scores_gemma":[0.9915098,0.0007256208,0.005969264,0.00005774385,0.000008975906,0.00001959247,0.0003740905,0.00003973866,0.001295097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000911481,"threshold_uncertainty_score":0.001851678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157405797372589,"score_gpt":0.2459073734881711,"score_spread":0.2301667937509122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}