{"id":"W2021424812","doi":"10.1158/1078-0432.ccr-08-2859","title":"Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors","year":2009,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada); Princess Margaret Cancer Centre","funders":"","keywords":"Pharmacokinetics; Tolerability; Medicine; Pharmacology; Toxicity; Pharmacodynamics; Volume of distribution; Peripheral blood mononuclear cell; Methyltransferase; Internal medicine; Adverse effect; Biology; In vitro; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001694958,0.0001458327,0.0003988869,0.0001579621,0.00007081774,0.00001087007,0.0002297106,0.0001335474,0.0000178078],"category_scores_gemma":[0.0003746133,0.0001220846,0.00006840059,0.0003063467,0.0002002889,0.00001160843,0.00007067696,0.0002976735,7.508631e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002197052,"about_ca_system_score_gemma":0.0001472859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002114544,"about_ca_topic_score_gemma":0.0005163706,"domain_scores_codex":[0.9970677,0.0008433013,0.000769977,0.0004917596,0.000523371,0.0003038998],"domain_scores_gemma":[0.9985682,0.00009222326,0.0001525651,0.0004857338,0.0005291988,0.0001721083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002939129,0.008692084,0.1047688,0.00001946013,0.00003848546,0.000008629222,0.0003361886,0.0001168265,0.8459149,0.000005509208,0.00001170899,0.03714823],"study_design_scores_gemma":[0.01080156,0.05543892,0.3183125,0.00007844083,0.00001838924,6.263387e-8,0.0002184766,0.00002029702,0.6147936,0.0001061505,0.00005801585,0.0001535703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987571,0.0001920833,0.00001397737,0.00004106354,0.00004064831,0.0008395149,0.00002711409,0.000004259647,0.00008423757],"genre_scores_gemma":[0.9994501,0.0002496921,0.00006307479,0.0000235814,0.00009040105,0.00002371809,0.00006012548,0.00002098197,0.00001836215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2311213,"threshold_uncertainty_score":0.4978465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06239328701490882,"score_gpt":0.4842561042323729,"score_spread":0.4218628172174641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}