{"id":"W2021428820","doi":"10.1073/pnas.1002199107","title":"Structural organization of the functional domains of <i>Clostridium difficile</i> toxins A and B","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Calgary","funders":"","keywords":"Glucosyltransferase; Clostridium difficile toxin A; Toxin; Endocytosis; Clostridium difficile; Biochemistry; Biology; Clostridium difficile toxin B; Glucosyltransferases; Endosome; Chemistry; Microbiology; Receptor; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006004531,0.0001015906,0.0002187068,0.0001436498,0.000166347,0.000009231716,0.0004204785,0.0001127827,0.00006646168],"category_scores_gemma":[0.001454696,0.00005676186,0.00008878174,0.00130673,0.001610135,0.0001400172,0.0002298099,0.0003233835,3.089002e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002580199,"about_ca_system_score_gemma":0.0001552436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001347064,"about_ca_topic_score_gemma":3.73445e-7,"domain_scores_codex":[0.9976586,0.000006824388,0.0004107181,0.000202017,0.001577081,0.0001448304],"domain_scores_gemma":[0.9984576,0.0001407353,0.0004458399,0.00002215071,0.0008843348,0.00004932966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003572983,0.00006068942,0.0417808,0.0001195166,0.00001984929,4.33333e-9,0.00009587038,0.00001191307,0.9429548,0.01444723,0.000295591,0.0001779473],"study_design_scores_gemma":[0.0003444557,0.00005710023,0.2528037,0.00006027615,0.00002782357,0.0000260524,0.0001327378,0.0002089331,0.7450744,0.001190948,0.00003377381,0.00003981272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946911,0.0000533162,3.345291e-7,0.003496309,0.00004854599,0.0002580671,0.00004437977,0.000005640283,0.001402314],"genre_scores_gemma":[0.9994639,0.00003107164,0.0001965779,0.00007274537,0.0001144981,0.000002472267,5.449413e-7,0.000005952988,0.000112291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2110229,"threshold_uncertainty_score":0.5932609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932734852503008,"score_gpt":0.2903399353746545,"score_spread":0.2610125868496245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}