{"id":"W2021452884","doi":"10.1158/1538-7445.am10-3097","title":"Abstract 3097: The leukemogenic protein E2A-PBX1 blocks B-lymphoid commitment in early hematopoietic progenitors","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Lymphopoiesis; Myeloid; Haematopoiesis; Biology; Progenitor cell; Bone marrow; CD19; Stromal cell; Interleukin 3; Immunophenotyping; Cancer research; B cell; Immunology; Leukemia; Molecular biology; Stem cell; T cell; Cell biology; Antibody; Antigen; Interleukin 21","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640711,0.0002773183,0.000228859,0.0001851304,0.0001555856,0.0002324079,0.000221995,0.0003079805,0.003702858],"category_scores_gemma":[0.0001111133,0.0001003488,0.0001526788,0.00009756122,0.0002292045,0.0001141085,0.0001637341,0.0006643976,0.0007876848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002131492,"about_ca_system_score_gemma":0.0002254544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003593512,"about_ca_topic_score_gemma":0.000397529,"domain_scores_codex":[0.9998384,0.0000404163,0.00001505209,0.00001701229,0.00004069667,0.00004856052],"domain_scores_gemma":[0.9998629,0.00005030954,0.00001942831,0.00001502297,0.000009731636,0.00004258654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002700611,0.0001816543,0.0001426692,0.00002467898,0.000004061841,0.00004866264,0.000008900698,0.00006194456,0.9980778,0.0001430991,0.00008874384,0.0009476967],"study_design_scores_gemma":[0.00003802426,0.0006912137,0.001443302,0.000005142727,0.000006508777,0.0001273949,0.00001124905,0.000515726,0.995374,0.00002952227,0.001756682,0.000001278106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952953,0.0008748813,0.001020727,0.0001055583,0.00002867445,0.00002706049,0.0003909893,0.00006573494,0.002191004],"genre_scores_gemma":[0.9899636,0.0005100596,0.001246591,0.00006512834,0.00001268362,0.00004829456,0.00130971,0.00003050627,0.006813432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003702858,"threshold_uncertainty_score":0.01238728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04155184444068739,"score_gpt":0.369512048476246,"score_spread":0.3279602040355586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}