{"id":"W2021460138","doi":"10.1016/j.freeradbiomed.2007.01.015","title":"ROS generation in endothelial hypoxia and reoxygenation stimulates MAP kinase signaling and kinase-dependent neutrophil recruitment","year":2007,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Institute of Infection and Immunity","funders":"","keywords":"Cell biology; Reactive oxygen species; Mitochondrial ROS; Antimycin A; Hypoxia (environmental); Phosphorylation; Signal transduction; Kinase; Intracellular; Oxidative stress; Mitochondrion; Biology; Chemistry; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009189671,0.000237535,0.0004028383,0.0002303841,0.0001995615,0.000006998247,0.00009477001,0.0003825814,0.0001421122],"category_scores_gemma":[0.0001899285,0.0001764643,0.00002118488,0.00008619935,0.0006822207,0.00006479157,0.00009869898,0.0003577936,0.000009560415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003929025,"about_ca_system_score_gemma":0.00002065217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001399752,"about_ca_topic_score_gemma":0.0001246977,"domain_scores_codex":[0.9983981,0.0002583452,0.0004218451,0.000494981,0.00004482616,0.0003819516],"domain_scores_gemma":[0.9993131,0.0002847758,0.0001005071,0.0001709848,0.00003883273,0.00009178946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003128826,0.00006382752,0.00129134,0.00001887305,0.00004820038,0.00006158493,0.0002696221,0.000001784182,0.967198,0.008389206,0.0002042538,0.02214044],"study_design_scores_gemma":[0.01341499,0.002997909,0.01774033,0.0001616949,0.0001387802,0.0002626151,0.0003444095,0.00009306837,0.9318696,0.01106395,0.02142082,0.0004918096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806807,0.01408571,0.001256901,0.002796701,0.0005235925,0.0005306546,0.00003370177,0.00003523398,0.00005677008],"genre_scores_gemma":[0.9967058,0.001314473,0.0003580988,0.0008736475,0.000315289,0.0000296537,0.0002197347,0.00001398305,0.0001693622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03532836,"threshold_uncertainty_score":0.7196003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03966753868091508,"score_gpt":0.2928978896055361,"score_spread":0.253230350924621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}