{"id":"W2021467687","doi":"10.1124/jpet.110.171017","title":"Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, Analgesic, Antipyretic, Antioxidant Prodrugs","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health","keywords":"Analgesic; Pharmacology; Prodrug; Antipyretic; Malondialdehyde; Aspirin; Anti-inflammatory; Carrageenan; Superoxide dismutase; Chemistry; Lipid peroxidation; Hyperalgesia; Cyclooxygenase; Medicine; Oxidative stress; Biochemistry; Enzyme; Nociception; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00158639,0.0006948427,0.001627475,0.0004401843,0.0004204683,0.0001003196,0.0003177487,0.0005676273,0.0004362182],"category_scores_gemma":[0.0000438899,0.0005789371,0.0003017409,0.0002433099,0.0007985592,0.0004121871,0.0001813976,0.001874798,0.00006557465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001093178,"about_ca_system_score_gemma":0.0003863158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000101308,"about_ca_topic_score_gemma":0.000001533188,"domain_scores_codex":[0.9962046,0.0004182338,0.001383025,0.0005335837,0.0006020151,0.0008585841],"domain_scores_gemma":[0.997246,0.0003456145,0.001021634,0.000305551,0.0003509855,0.0007302033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001810325,0.0004769871,0.09061411,0.0001666166,0.001055555,0.0002975723,0.001566349,0.000003500707,0.9010555,0.0001064348,0.001276865,0.001570216],"study_design_scores_gemma":[0.00937885,0.002854656,0.05011702,0.0001128869,0.001168315,0.001244056,0.0005217823,0.0005597126,0.9099881,0.00009693186,0.02334006,0.0006176537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888539,0.005480782,0.00002906067,0.001646959,0.002604224,0.0008294517,0.00001582581,0.00006758731,0.000472179],"genre_scores_gemma":[0.9924378,0.001635305,0.0008967083,0.002316318,0.002422019,0.00001859187,0.000009421204,0.0001030105,0.0001608468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04049709,"threshold_uncertainty_score":0.9996662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864408906151564,"score_gpt":0.3576107425474468,"score_spread":0.3389666534859311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}