{"id":"W2021469685","doi":"10.1042/0264-6021:3600127","title":"Replication of HIV-1 viruses in the presence of the Portland α1-antitrypsin variant (α1-PDX) inhibitor","year":2001,"lang":"fr","type":"article","venue":"Biochemical Journal","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Gp41; Infectivity; Biology; Jurkat cells; Ectodomain; Transfection; Molecular biology; Viral replication; Virology; Cell fusion; Furin; Cell culture; Virus; Biochemistry; T cell; Epitope; Antibody; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008574433,0.0001429434,0.0002516155,0.00006679634,0.0001244897,0.0000191558,0.0005824153,0.0002609886,0.0004911474],"category_scores_gemma":[0.0009195795,0.00007833348,0.0001712203,0.0003021255,0.0007092815,0.00006862253,0.0001213592,0.0006706618,0.0000756206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006058484,"about_ca_system_score_gemma":0.0002391065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001879115,"about_ca_topic_score_gemma":0.00002008146,"domain_scores_codex":[0.9980584,0.0006024429,0.0005741774,0.0002322107,0.000158509,0.0003741929],"domain_scores_gemma":[0.99853,0.0002998241,0.0003339759,0.0006041647,0.0001832079,0.00004881909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005451708,0.001221926,0.06239102,0.00004768673,0.0002010957,0.00009886538,0.000602459,0.000002909395,0.8512771,0.000496819,0.07984144,0.003273563],"study_design_scores_gemma":[0.002553931,0.0003965889,0.08513188,0.0006154947,0.0001226689,0.003855179,0.0004709833,0.000009611586,0.820808,0.0006801083,0.08519471,0.0001608372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677357,0.02341694,0.00007362224,0.007124044,0.0005073364,0.0002882177,0.0001453035,0.00000299998,0.0007058145],"genre_scores_gemma":[0.9956741,0.002602826,0.000091653,0.000107122,0.000199368,0.000008504801,0.00002313962,0.000007645353,0.001285694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03046903,"threshold_uncertainty_score":0.537772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02477586579481188,"score_gpt":0.2907858933931351,"score_spread":0.2660100275983232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}