{"id":"W2021483935","doi":"10.1158/1538-7445.pedcan-a20","title":"Abstract A20: hTERT promoter hypermethylation is a cancer signature which predicts survival and response to targeted therapy in pediatric nervous system tumors","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hospital for Sick Children","funders":"","keywords":"Telomerase; Methylation; Telomerase reverse transcriptase; DNA methylation; Cancer; Cancer research; Malignancy; Biomarker; Oncology; Medicine; Targeted therapy; Biology; Internal medicine; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368594,0.0002559376,0.0003096685,0.0004028476,0.0001481821,0.0002965115,0.000179947,0.0002203028,0.001344529],"category_scores_gemma":[0.001085187,0.0001065486,0.0001967548,0.0004071188,0.0001479396,0.0001459847,0.0001832744,0.0002408664,0.00025797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002951321,"about_ca_system_score_gemma":0.0002716421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001802511,"about_ca_topic_score_gemma":0.002340088,"domain_scores_codex":[0.999899,0.00001587296,0.000009963963,0.00003123751,0.00002959181,0.00001430243],"domain_scores_gemma":[0.999421,0.0001592284,0.000229081,0.00002600173,0.00008303326,0.00008167138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007334471,0.00003692621,0.9641737,0.00003190256,0.00005740468,0.0002560329,0.00003162801,0.0003458995,0.02319751,0.00002026692,0.0003346934,0.01078063],"study_design_scores_gemma":[0.00001482433,0.0001863458,0.9869215,0.000007464027,0.00006702937,0.001749458,0.00003341099,0.001137145,0.009461633,0.00004637604,0.0003712994,0.000003541207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9984262,0.0002584886,0.0002782522,0.00002640842,0.000002941472,0.000006762066,0.000715004,0.00001675966,0.0002692292],"genre_scores_gemma":[0.9977544,0.0001394165,0.0005378481,0.00001514485,0.00000542506,0.00001108077,0.001322379,0.000006324623,0.0002078953],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001802511,"threshold_uncertainty_score":0.004497886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04295232720178995,"score_gpt":0.3618817671923871,"score_spread":0.3189294399905971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}