{"id":"W2021485996","doi":"10.1210/en.2013-1050","title":"Hemin Therapy Improves Kidney Function in Male Streptozotocin-Induced Diabetic Rats: Role of the Heme Oxygenase/Atrial Natriuretic Peptide/Adiponectin Axis","year":2013,"lang":"en","type":"article","venue":"Endocrinology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"University of Saskatchewan; Heart and Stroke Foundation of Canada","keywords":"Internal medicine; Endocrinology; Proinflammatory cytokine; Heme oxygenase; Diabetic nephropathy; Medicine; Atrial natriuretic peptide; Adiponectin; Kidney; Inflammation; Chemistry; Diabetes mellitus; Insulin resistance; Heme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407504,0.0002958897,0.0003429725,0.000107125,0.00007429018,0.00001946338,0.0004032408,0.0002660874,0.0003148939],"category_scores_gemma":[0.0002662863,0.0002355436,0.0002862788,0.0002221309,0.0001406137,0.00001112535,0.0001735901,0.0002900886,0.00004157117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003853379,"about_ca_system_score_gemma":0.0001974556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005842714,"about_ca_topic_score_gemma":0.0001286006,"domain_scores_codex":[0.9978966,0.0002447141,0.0004976375,0.0005570836,0.00017352,0.000630519],"domain_scores_gemma":[0.9987991,0.00004322314,0.0001982236,0.0007201012,0.0001048963,0.0001343832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000154019,0.00008848992,0.01017975,0.00001399846,0.00009326379,0.000002883599,0.0000690626,0.000007924065,0.9814932,0.00007514775,0.001684829,0.006137438],"study_design_scores_gemma":[0.001858101,0.0006391283,0.01915486,0.00001363207,0.00002338304,0.00002873521,0.0003431139,0.00004079623,0.9661785,0.0003583983,0.01109621,0.0002651219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952218,0.001548056,0.000007730771,0.0004914362,0.0004900495,0.0008920881,0.00001522608,0.00002133215,0.001312286],"genre_scores_gemma":[0.997513,0.0001883077,0.00005808464,0.0006483027,0.0003676733,0.0002136973,0.00004046579,0.00004073847,0.0009297077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01531468,"threshold_uncertainty_score":0.960519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006792243151890094,"score_gpt":0.2145660085391013,"score_spread":0.2077737653872113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}