{"id":"W2021496158","doi":"10.1002/anie.200603945","title":"Enantioselective Total Synthesis of (+)‐Homochelidonine by a Pd<sup>II</sup>‐Catalyzed Asymmetric Ring‐Opening Reaction of a <i>meso</i>‐Azabicyclic Alkene with an Aryl Boronic Acid","year":2006,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Enantioselective synthesis; Alkene; Chemistry; Ring (chemistry); Boronic acid; Aryl; Catalysis; Stereochemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000200512,0.0003297127,0.0004665414,0.0001922727,0.0001053311,0.00003873344,0.0003226118,0.0002245937,0.0004587017],"category_scores_gemma":[0.0003083387,0.0003060284,0.0001987158,0.000424039,0.0001503239,0.0006006628,0.00008582293,0.0002635446,0.00000507844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003421745,"about_ca_system_score_gemma":0.00007384646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000847078,"about_ca_topic_score_gemma":0.00002362751,"domain_scores_codex":[0.997722,0.00001559027,0.0006556807,0.0005435164,0.0007411281,0.0003221366],"domain_scores_gemma":[0.9983495,0.0002551626,0.0006070276,0.0003009839,0.0003869669,0.0001002926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004360927,0.0007550708,0.0005650644,0.00009030673,0.0002118383,0.000004639584,0.00007682695,0.00003482428,0.9936936,0.00007778699,0.001182877,0.002871004],"study_design_scores_gemma":[0.00110764,0.00009152121,0.0005688747,0.0003460541,0.0001428239,0.00005949185,0.0001526588,0.0003203326,0.9959096,0.0002183002,0.000748718,0.000333999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854555,0.0002683586,0.0003404134,0.0001842919,0.00007379607,0.0001017056,0.0005876647,0.00008243791,0.01290585],"genre_scores_gemma":[0.9960421,0.00007532636,0.0003924476,0.00001657769,0.0008588629,0.00009868894,0.002087136,0.00005106957,0.0003777992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01252805,"threshold_uncertainty_score":0.9999392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005203972213195414,"score_gpt":0.2133016302599152,"score_spread":0.2080976580467198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}