{"id":"W2021523247","doi":"10.3851/imp1565","title":"Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity","year":2010,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Gilead Sciences","keywords":"Foscarnet; Recombinant DNA; Biology; Molecular biology; DNA polymerase; Virology; Polymerase; Ganciclovir; Aphidicolin; Human cytomegalovirus; Mutant; Virus; Enzyme; Wild type; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003200791,0.0004677706,0.0004119052,0.0002714554,0.00008533828,0.0004740741,0.0002864529,0.0005223754,0.001570572],"category_scores_gemma":[0.0007498554,0.0001601495,0.0002735456,0.0001288299,0.0003675643,0.0002733761,0.0002244115,0.0005887224,0.0002988999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003040127,"about_ca_system_score_gemma":0.0001633843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002894336,"about_ca_topic_score_gemma":0.0002853399,"domain_scores_codex":[0.9994973,0.00009522826,0.00007113037,0.000133223,0.0001201987,0.00008294533],"domain_scores_gemma":[0.9991805,0.0003511546,0.0001603132,0.00009615697,0.00008196802,0.000129898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004086551,0.0000543601,0.001974765,0.00006584312,0.00001973963,0.0001823484,0.00001754894,0.0001519137,0.9950091,0.00005418764,0.00002091544,0.002040693],"study_design_scores_gemma":[0.00002440159,0.0009660031,0.006146655,0.000007135407,0.00003832781,0.001558171,0.00002132928,0.0008035158,0.9899361,0.00003520893,0.0004567815,0.000006256283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977027,0.0013033,0.0004242389,0.00002943243,0.00001254639,0.00001081613,0.0001147902,0.00002375167,0.000378564],"genre_scores_gemma":[0.9988071,0.0002189521,0.0006005251,0.00001597559,0.0000055037,0.000007491566,0.0001369659,0.000006882696,0.0002006216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570572,"threshold_uncertainty_score":0.005254149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751284479558043,"score_gpt":0.3454441440701906,"score_spread":0.3179312992746102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}