{"id":"W2021531902","doi":"10.1016/j.bcmd.2014.05.004","title":"A Phase 3, multicenter, open-label, switchover trial to assess the safety and efficacy of taliglucerase alfa, a plant cell-expressed recombinant human glucocerebrosidase, in adult and pediatric patients with Gaucher disease previously treated with imiglucerase","year":2014,"lang":"en","type":"article","venue":"Blood Cells Molecules and Diseases","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"Pfizer","keywords":"Medicine; Enzyme replacement therapy; Adverse effect; Regimen; Pediatrics; Clinical trial; Glucocerebrosidase; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00123574,0.001665371,0.002471044,0.0003819945,0.0004673401,0.001229454,0.0007570011,0.001616938,0.003576345],"category_scores_gemma":[0.0009151485,0.0004450595,0.001511646,0.0003658977,0.001393852,0.001534946,0.0003195413,0.004388718,0.000815202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001035558,"about_ca_system_score_gemma":0.001144538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008637584,"about_ca_topic_score_gemma":0.001392887,"domain_scores_codex":[0.9995736,0.0001439725,0.00001590785,0.0001095232,0.0000322266,0.000124768],"domain_scores_gemma":[0.9991541,0.0001623379,0.0001058905,0.00009781032,0.00004078935,0.0004391823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8988087,0.02994392,0.004251966,0.0002230633,0.001181104,0.0003134103,0.000221231,0.001124576,0.02562538,0.0003448816,0.002422697,0.03553909],"study_design_scores_gemma":[0.7037772,0.2828519,0.007439384,0.0000167896,0.0003286312,0.0002826116,0.00006283542,0.001024449,0.002589569,0.0003303894,0.001268479,0.0000277745],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994688,0.001195467,0.0005714804,0.0003861472,0.0001647981,0.0009085973,0.0008507565,0.0001121119,0.001122702],"genre_scores_gemma":[0.9929212,0.0006183755,0.0009277863,0.0009923943,0.0001578118,0.001117808,0.001837366,0.00004157942,0.001385841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003576345,"threshold_uncertainty_score":0.01196402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469185883754787,"score_gpt":0.2760670800623602,"score_spread":0.2613752212248123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}