{"id":"W2021533548","doi":"10.1074/jbc.m111.337907","title":"Silent Information Regulator 2 (Sir2) and Forkhead Box O (FOXO) Complement Mitochondrial Dysfunction and Dopaminergic Neuron Loss in Drosophila PTEN-induced Kinase 1 (PINK1) Null Mutant","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation of Korea; National Research Foundation; Ministry of Education, Science and Technology; Manitoba Health Research Council","keywords":"PINK1; Biology; Parkin; Mitochondrion; Cell biology; Mitophagy; Kinase; Gene knockdown; Molecular biology; Genetics; Parkinson's disease; Autophagy; Gene; Apoptosis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940839,0.0006305642,0.0003859191,0.000421011,0.0001420584,0.0002791042,0.0002907926,0.0003782446,0.001892339],"category_scores_gemma":[0.0001331672,0.0001865003,0.0004095676,0.000154893,0.0002727859,0.0002804344,0.0003972976,0.0005760679,0.000379594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002194381,"about_ca_system_score_gemma":0.0002436806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004910579,"about_ca_topic_score_gemma":0.0009141324,"domain_scores_codex":[0.9998226,0.00001972541,0.00001884169,0.0000391962,0.0000599598,0.00003981143],"domain_scores_gemma":[0.9998216,0.00001473345,0.00007061259,0.00001440287,0.00001234181,0.00006632616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001329975,0.00003172985,0.0002004964,0.0000535744,0.00001116498,0.00005952475,0.00001159923,0.00007468162,0.9977434,0.0001306308,0.0000723105,0.001477967],"study_design_scores_gemma":[0.0000935052,0.0008397999,0.004842839,0.00001162465,0.00007825322,0.0004212759,0.00004704724,0.002862841,0.9848872,0.0001178061,0.005783128,0.00001460217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852503,0.003394228,0.007607957,0.0001996705,0.0001046348,0.0000360707,0.0004432061,0.0004799874,0.002484028],"genre_scores_gemma":[0.9877801,0.001440002,0.003985243,0.0001421526,0.00002614672,0.00005377041,0.0008572484,0.00005881794,0.005656607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892339,"threshold_uncertainty_score":0.00633049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03358245224616382,"score_gpt":0.2522069990383459,"score_spread":0.218624546792182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}