{"id":"W2021533548","doi":"10.1074/jbc.m111.337907","title":"Silent Information Regulator 2 (Sir2) and Forkhead Box O (FOXO) Complement Mitochondrial Dysfunction and Dopaminergic Neuron Loss in Drosophila PTEN-induced Kinase 1 (PINK1) Null Mutant","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation of Korea; National Research Foundation; Ministry of Education, Science and Technology; Manitoba Health Research Council","keywords":"PINK1; Biology; Parkin; Mitochondrion; Cell biology; Mitophagy; Kinase; Gene knockdown; Molecular biology; Genetics; Parkinson's disease; Autophagy; Gene; Apoptosis; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783059,0.0001573747,0.0002541493,0.00004705471,0.00008922282,0.00005990416,0.0001070399,0.000142178,0.00008126911],"category_scores_gemma":[0.0003096758,0.0001103177,0.00006378097,0.0001026313,0.00008800079,0.0003595164,0.00008391481,0.0003301456,0.000002961037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006876505,"about_ca_system_score_gemma":0.00001557008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003420682,"about_ca_topic_score_gemma":2.034607e-7,"domain_scores_codex":[0.9987367,0.00005972151,0.0005454049,0.0001511505,0.0002313764,0.0002756093],"domain_scores_gemma":[0.9992094,0.00009960966,0.0003592274,0.00008743993,0.00004155115,0.0002027734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002662432,0.0001115598,0.002164131,0.00003043659,0.000002811388,0.00001400043,0.00009330985,0.000007117758,0.9955548,0.00006959772,0.00005166217,0.00163431],"study_design_scores_gemma":[0.002197935,0.0004461386,0.01076293,0.00008325911,0.00001449085,0.0004968178,0.0001577755,0.0003481068,0.9806919,0.0002965796,0.004281424,0.0002226062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989504,0.0001028691,0.0000503042,0.0002805109,0.0003655455,0.0001118153,0.000007422612,0.00001168207,0.0001194463],"genre_scores_gemma":[0.9990724,0.0001150135,0.0001216929,0.0002120381,0.0004606633,0.000002422445,0.000003738613,0.000006317219,0.000005705131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01486288,"threshold_uncertainty_score":0.4498625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03358245224616382,"score_gpt":0.2522069990383459,"score_spread":0.218624546792182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}