{"id":"W2021553032","doi":"10.1016/j.jhep.2014.10.035","title":"Twenty-eight day safety, antiviral activity, and pharmacokinetics of tenofovir alafenamide for treatment of chronic hepatitis B infection","year":2014,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Janssen Pharmaceuticals; British Microcirculation Society; Gilead Sciences; Novartis; Gilead UK and Ireland Corporate Contributions; Roche; Merck; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"Tenofovir alafenamide; Medicine; Tenofovir; Pharmacokinetics; Virology; Chronic hepatitis; Hepatitis B; Human immunodeficiency virus (HIV); Pharmacology; Virus; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007906476,0.0004203209,0.0007308609,0.0002410923,0.0002475541,0.0003824689,0.0002448514,0.0003893699,0.001162575],"category_scores_gemma":[0.002151272,0.00019984,0.0003402934,0.0001429104,0.0003390627,0.0005649714,0.0001533349,0.0006710489,0.0002136523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002594376,"about_ca_system_score_gemma":0.0003123554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004520531,"about_ca_topic_score_gemma":0.000504605,"domain_scores_codex":[0.9996401,0.0001762282,0.00003142502,0.00003806448,0.00004873277,0.00006543393],"domain_scores_gemma":[0.9992701,0.0002337371,0.0001578587,0.00007827592,0.00006977924,0.0001901736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4813617,0.01407109,0.06053336,0.0003700802,0.0005787022,0.0007257094,0.0006015898,0.002382225,0.2137657,0.0002922376,0.001143204,0.2241744],"study_design_scores_gemma":[0.02963343,0.4573254,0.4242043,0.00009136668,0.0008204418,0.002251604,0.0005154413,0.005125947,0.07343452,0.0005297985,0.005886524,0.0001812198],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990584,0.0004186059,0.0001248161,0.00003302062,0.00001231647,0.00001677624,0.00006372581,0.00001383442,0.0002585559],"genre_scores_gemma":[0.9992182,0.0001536591,0.00007539876,0.00002463478,0.00002050881,0.00002049401,0.00008396464,0.000003912985,0.0003992137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001162575,"threshold_uncertainty_score":0.004181385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174453499360699,"score_gpt":0.3072132648366535,"score_spread":0.2897679149005836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}