{"id":"W2021575456","doi":"10.4161/isl.18338","title":"Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells","year":2012,"lang":"en","type":"review","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emmanuel Bible College; Regional Municipality of Waterloo; University of Waterloo","funders":"","keywords":"Cytosol; Glycolysis; Glucose transporter; Mitochondrial matrix; Hexokinase; Biology; Glucose homeostasis; Cell biology; Biochemistry; Secretion; Insulin; Chemistry; Metabolism; Endocrinology; Insulin resistance; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685471,0.0007026473,0.001238724,0.001317727,0.0002744073,0.0007457848,0.0006484109,0.0008306892,0.001517087],"category_scores_gemma":[0.0002519248,0.0002196319,0.0003034168,0.001240063,0.0003803779,0.001157907,0.0005403179,0.001090491,0.001671342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004730251,"about_ca_system_score_gemma":0.0006179661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006544608,"about_ca_topic_score_gemma":0.0008173815,"domain_scores_codex":[0.9998899,0.00001618206,0.0000189966,0.00001825976,0.00004626259,0.00001045048],"domain_scores_gemma":[0.9999171,0.00002706572,0.00001659979,0.00000334817,0.00002524485,0.00001055927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009624867,0.00008988627,0.0002288426,0.02105308,0.0000524444,0.0006056268,0.0001085057,0.0005982606,0.01258053,0.005913264,0.01347297,0.9452003],"study_design_scores_gemma":[0.00001961831,0.0001338038,0.001504753,0.002111436,0.00007672634,0.003125943,0.0001180048,0.0001824903,0.003698492,0.003093113,0.9859077,0.00002790388],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004268844,0.997323,0.0004264303,0.0001815672,0.0001515105,0.000006136589,0.0000140649,0.00001537552,0.001455003],"genre_scores_gemma":[0.001291783,0.9974764,0.0003689193,0.00009226325,0.0000973207,0.000007471531,0.00001829821,0.000001422193,0.000646074],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001517087,"threshold_uncertainty_score":0.005075157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077947097034932,"score_gpt":0.2923461298168445,"score_spread":0.2615666588464952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}