{"id":"W2021592359","doi":"10.1016/j.ygcen.2015.01.013","title":"Inhibition of spawning in zebrafish (Danio rerio): Adverse outcome pathways of quinacrine and ethinylestradiol","year":2015,"lang":"en","type":"article","venue":"General and Comparative Endocrinology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Water Network","keywords":"Biology; Ovulation; Internal medicine; Endocrinology; Toxicant; Follicular phase; Ovarian follicle; Ovary; Zebrafish; Follicle-stimulating hormone receptor; Vitellogenesis; Oocyte; GPER; Estrogen receptor; Luteinizing hormone; Hormone; Cell biology; Follicle-stimulating hormone; Gene; Toxicity; Embryo; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594205,0.0002683582,0.0002242307,0.0001900997,0.0001703803,0.0001904872,0.0002376681,0.0002881066,0.001534604],"category_scores_gemma":[0.0001344116,0.0001744809,0.0002952528,0.000081546,0.0002459668,0.0001930745,0.0001811265,0.0003851545,0.0001608287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004138959,"about_ca_system_score_gemma":0.0003510413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002312378,"about_ca_topic_score_gemma":0.005218798,"domain_scores_codex":[0.9999052,0.00001442167,0.000009050493,0.00001814735,0.000021488,0.00003162809],"domain_scores_gemma":[0.9998729,0.00001804543,0.00004580541,0.00001061735,0.00002550143,0.00002706171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005456256,0.00002174392,0.0006389202,0.00003862634,0.000008752472,0.00009255378,0.00001952988,0.00007488404,0.9973915,0.0001754768,0.00007344216,0.0009188386],"study_design_scores_gemma":[0.00006660909,0.001047856,0.02348494,0.000009127487,0.00005561647,0.0002009363,0.0001393091,0.0006822452,0.9722933,0.0001238868,0.001886401,0.00000974212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959203,0.0008560526,0.0008422922,0.0002541377,0.00003048915,0.0000174686,0.0002774567,0.0000597235,0.001742047],"genre_scores_gemma":[0.9959175,0.0006759387,0.0004278625,0.00006840004,0.000006208962,0.00002162623,0.0001542248,0.00001151862,0.002716693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002312378,"threshold_uncertainty_score":0.005133808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0911605253811744,"score_gpt":0.3080137703709299,"score_spread":0.2168532449897555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}