{"id":"W2021594707","doi":"10.1016/j.bbrc.2012.12.129","title":"Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis","year":2013,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Genome Alberta; Alberta Innovates - Technology Futures; Genome Canada; University of Calgary; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Government of Alberta","keywords":"Sanguinarine; Benzylisoquinoline; Protopine; Papaveraceae; Opium Poppy; Papaver; Thebaine; Biochemistry; Complementary DNA; Biosynthesis; Methyl jasmonate; Biology; Chemistry; Alkaloid; Enzyme; Stereochemistry; Gene; Botany; Codeine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004299854,0.00013392,0.0003158903,0.0002693763,0.0001238047,0.00005214976,0.0002839534,0.0001324402,0.00009903564],"category_scores_gemma":[0.0008880561,0.0001106971,0.00005112492,0.0007227458,0.0006522095,0.0001546978,0.0006315747,0.0005333228,0.00002388513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005112559,"about_ca_system_score_gemma":0.00006901749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695934,"about_ca_topic_score_gemma":0.00001983347,"domain_scores_codex":[0.9983572,0.0002570515,0.0003470972,0.000312548,0.0004067299,0.0003193623],"domain_scores_gemma":[0.9978003,0.0008300415,0.0000555644,0.0007126046,0.0003488465,0.0002526701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000879486,0.0004651569,0.002824789,0.00008101311,0.0000209134,0.000001484923,0.0001664028,1.12935e-8,0.9876321,0.0004133442,0.00008742619,0.008219393],"study_design_scores_gemma":[0.00097391,0.0003594991,0.1275807,0.0003777594,0.0000240121,0.000005185356,0.0001683611,0.007598116,0.8608732,0.001006879,0.0008488254,0.0001834761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876925,0.0004911557,0.0000635762,0.01068495,0.000006706537,0.000517116,0.00004570411,0.00001954878,0.0004787041],"genre_scores_gemma":[0.9950382,0.002134817,0.002112009,0.00005331444,0.00008574382,0.0001157302,0.0002742239,0.00001495122,0.0001710532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1267589,"threshold_uncertainty_score":0.4514096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05935606625640102,"score_gpt":0.3525391028081288,"score_spread":0.2931830365517277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}