{"id":"W2021594707","doi":"10.1016/j.bbrc.2012.12.129","title":"Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis","year":2013,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Genome Alberta; Alberta Innovates - Technology Futures; Genome Canada; University of Calgary; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Government of Alberta","keywords":"Sanguinarine; Benzylisoquinoline; Protopine; Papaveraceae; Opium Poppy; Papaver; Thebaine; Biochemistry; Complementary DNA; Biosynthesis; Methyl jasmonate; Biology; Chemistry; Alkaloid; Enzyme; Stereochemistry; Gene; Botany; Codeine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741158,0.0004983878,0.0003937978,0.0002704425,0.00024391,0.0003866936,0.0002681973,0.0003128833,0.0008785274],"category_scores_gemma":[0.0003296401,0.0002386568,0.0005247516,0.0002861008,0.0003499618,0.0002543261,0.0003203713,0.0006657128,0.0006540085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000427202,"about_ca_system_score_gemma":0.0006301546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002646416,"about_ca_topic_score_gemma":0.002418256,"domain_scores_codex":[0.9998822,0.0000110488,0.000009754087,0.00003026458,0.00003103694,0.0000356672],"domain_scores_gemma":[0.9995884,0.0001463888,0.00005947835,0.00005490125,0.00006050858,0.00009028426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002913935,0.000008859878,0.0001188726,0.00001373955,0.000002708896,0.00006749616,0.00001815718,0.00003161738,0.9990911,0.0000503239,0.00001281313,0.0005551275],"study_design_scores_gemma":[0.00002997511,0.0002194862,0.02053587,0.00001121085,0.00008178582,0.0009385138,0.0001786017,0.00167674,0.9696131,0.0001867911,0.006508556,0.00001935665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856801,0.0007585291,0.009261872,0.0003975235,0.00005730092,0.00007086936,0.002006543,0.0000859813,0.001681197],"genre_scores_gemma":[0.970853,0.001035238,0.008976862,0.0001451168,0.00004798495,0.00005139488,0.01130024,0.0001052836,0.00748484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002646416,"threshold_uncertainty_score":0.005261958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05935606625640102,"score_gpt":0.3525391028081288,"score_spread":0.2931830365517277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}