{"id":"W2021630699","doi":"10.1210/en.2009-0455","title":"Gonadotropin-Releasing Hormone-Mediated Phosphorylation of Estrogen Receptor-α Contributes to fosB Expression in Mouse Gonadotrophs","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Child and Family Research Institute","keywords":"GNRHR; Transactivation; Gonadotropic cell; Hormone response element; PCAF; CREB-binding protein; Small interfering RNA; Endocrinology; Biology; Internal medicine; Gonadotropin-releasing hormone; Gene knockdown; CREB; Estrogen receptor; Coactivator; Transcription factor; Transfection; Pituitary gland; Luteinizing hormone; Cell culture; Medicine; Gene; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002339093,0.000384795,0.0002590987,0.0007624337,0.0002532459,0.0004198752,0.0002529231,0.0003184908,0.003765593],"category_scores_gemma":[0.0001354057,0.0005679287,0.0005285506,0.0002690817,0.0003934306,0.0003066518,0.0002854333,0.001033268,0.001550733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004267512,"about_ca_system_score_gemma":0.0002856887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007408218,"about_ca_topic_score_gemma":0.001137736,"domain_scores_codex":[0.9997352,0.00001663304,0.00002271975,0.00008280273,0.00007716849,0.00006538557],"domain_scores_gemma":[0.9998131,0.00001437189,0.00004249857,0.00002267174,0.00002777233,0.00007952176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001099495,0.00001086776,0.0001087003,0.00002421304,0.000002314379,0.00002346734,0.00001551295,0.000007940788,0.9990067,0.00007014832,0.00002773406,0.0005925752],"study_design_scores_gemma":[0.00006292683,0.0002062093,0.0100543,0.00002241866,0.00001708283,0.0003961978,0.00007857427,0.0003075568,0.9812639,0.0001143342,0.007468354,0.00000817158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780173,0.003870142,0.008239521,0.0004312495,0.0001839952,0.00009106269,0.002991886,0.000253221,0.005921529],"genre_scores_gemma":[0.9386578,0.004348945,0.008655904,0.0004041829,0.0001061968,0.0003035227,0.0050443,0.0003276058,0.04215156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003765593,"threshold_uncertainty_score":0.01259714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005697508106438058,"score_gpt":0.2379459954589097,"score_spread":0.2322484873524716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}