{"id":"W2021635654","doi":"10.1038/clpt.2013.2","title":"Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants","year":2013,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":453,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; National Institute of General Medical Sciences; National Institute of Mental Health; National Heart, Lung, and Blood Institute; American Lebanese Syrian Associated Charities; Canadian Institutes of Health Research; Agency for Healthcare Research and Quality; National Institutes of Health","keywords":"Doxepin; Nortriptyline; Desipramine; Tricyclic; CYP2D6; Pharmacology; Pharmacogenetics; Clomipramine; CYP2C19; Dosing; Active metabolite; Medicine; Imipramine; Pharmacokinetics; Amitriptyline; Genotype; Chemistry; Internal medicine; Antidepressant; Cytochrome P450; Metabolism; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01854868,0.00090154,0.001943375,0.002490684,0.001111522,0.001915493,0.00453594,0.006701755,0.006588667],"category_scores_gemma":[0.03698706,0.0007976465,0.003085108,0.002976875,0.0007369782,0.001255777,0.001661238,0.006450461,0.006596321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001799379,"about_ca_system_score_gemma":0.008742095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01248081,"about_ca_topic_score_gemma":0.01627866,"domain_scores_codex":[0.972386,0.01156388,0.007118698,0.0008401446,0.00712862,0.0009626161],"domain_scores_gemma":[0.9470297,0.01570417,0.006271164,0.002189049,0.02698587,0.001820018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005276611,0.0008323292,0.01294876,0.001579251,0.0001993081,0.001448753,0.0005474106,0.002422222,0.003164331,0.006386033,0.6565062,0.3134377],"study_design_scores_gemma":[0.0008679144,0.0007424302,0.05525051,0.007559663,0.0003785286,0.003899295,0.0004630859,0.003819654,0.004435182,0.006507307,0.9159197,0.0001568472],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.02730071,0.05565486,0.2159538,0.2799588,0.009587639,0.01665854,0.02294219,0.005860328,0.3660831],"genre_scores_gemma":[0.1227572,0.04551492,0.5030304,0.1512224,0.005668949,0.02851509,0.04912497,0.001808624,0.09235746],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01854868,"threshold_uncertainty_score":0.09809595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2465648872691833,"score_gpt":0.5759832517471809,"score_spread":0.3294183644779976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}