{"id":"W2021667248","doi":"10.1139/y06-036","title":"Effect of fasudil on macrovascular disorder-induced endothelial dysfunction","year":2006,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Fasudil; Endothelial dysfunction; Enos; Endocrinology; Internal medicine; Thiobarbituric acid; Superoxide; Oxidative stress; Phenylephrine; Medicine; TBARS; Chemistry; Reactive oxygen species; Nitric oxide; Blood pressure; Nitric oxide synthase; Biochemistry; Lipid peroxidation; Rho-associated protein kinase; Kinase; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002879469,0.0001563184,0.0004978228,0.0002541392,0.0001167995,0.000001721732,0.00006797868,0.0001721075,0.0009532458],"category_scores_gemma":[0.00002045097,0.0001195357,0.0001582786,0.00008421516,0.0002215765,0.00003795951,0.000007014375,0.000352315,0.00001258157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007571862,"about_ca_system_score_gemma":0.0003203729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020623,"about_ca_topic_score_gemma":0.000413302,"domain_scores_codex":[0.9989139,0.000332424,0.0002779657,0.0001448932,0.00006251007,0.0002683347],"domain_scores_gemma":[0.9991891,0.0002203297,0.0001806328,0.00007108427,0.00008478427,0.0002540446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002014033,0.000148596,0.009681182,0.0001410528,0.000480291,0.0003240576,0.00005726212,0.00008621229,0.9813448,0.0001455093,0.002724324,0.00285263],"study_design_scores_gemma":[0.009085665,0.007758634,0.04617851,0.00002750861,0.000934448,0.0004334625,0.000009179296,0.00002538593,0.9298837,0.0003653603,0.005196748,0.0001014009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969055,0.0007809904,0.000005642637,0.0005835499,0.001067505,0.00021776,0.0000176214,0.00000474514,0.0004166981],"genre_scores_gemma":[0.9986366,0.00008710312,0.00001212279,0.0006519803,0.0004884062,0.000007075857,0.00001228936,0.00001028314,0.00009413024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05146116,"threshold_uncertainty_score":0.99996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006837914651812019,"score_gpt":0.263485123847406,"score_spread":0.256647209195594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}