{"id":"W2021669959","doi":"10.3109/14756366.2011.596836","title":"Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds","year":2011,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Carbonic anhydrase; Chemistry; Isozyme; Molecule; Enzyme; Bisphenol A; Bisphenol; Carbonic anhydrase II; Stereochemistry; Biochemistry; Thiadiazoles; Bromophenol blue; Medicinal chemistry; Organic chemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003122219,0.0001765402,0.0003297862,0.00008132324,0.00009188643,0.000008546865,0.00003452733,0.0001596494,0.00005496842],"category_scores_gemma":[0.00005696519,0.0001437663,0.00005533301,0.00009445751,0.0005076128,0.00003758821,0.00005518572,0.0001831445,4.832907e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000118585,"about_ca_system_score_gemma":0.00007069141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002250648,"about_ca_topic_score_gemma":0.00001203928,"domain_scores_codex":[0.9989076,0.00004108201,0.0005086872,0.0001915138,0.0002179141,0.0001331579],"domain_scores_gemma":[0.9988915,0.00001300781,0.0005379821,0.0001190813,0.0002806262,0.000157859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006016631,0.0001352547,0.0006603319,0.0002809839,0.00005985236,0.00001543971,0.0005433293,5.61114e-7,0.9968556,0.000104038,0.0005644038,0.0001784961],"study_design_scores_gemma":[0.002140651,0.002743424,0.0007039144,0.0005175168,0.0001164848,0.001187014,0.001674831,0.000003493081,0.990126,0.0002826481,0.0003569144,0.0001471234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953535,0.002127731,0.0002031443,0.0001116382,0.000033857,0.00007234486,0.0000149965,0.000004922312,0.00207787],"genre_scores_gemma":[0.9983069,0.0005989416,0.000616211,0.0001008318,0.0001543783,0.000002938873,0.00003239408,0.00001461332,0.0001727898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006729661,"threshold_uncertainty_score":0.5862618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468485414229435,"score_gpt":0.231914676370206,"score_spread":0.2172298222279117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}