{"id":"W2021703422","doi":"10.1038/onc.2008.136","title":"Intestinal tumor progression is promoted by decreased apoptosis and dysregulated Wnt signaling in Ceacam1−/− mice","year":2008,"lang":"en","type":"article","venue":"Oncogene","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Alexandra Hospital; McGill University Health Centre; University of Alberta; McGill University","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Wnt signaling pathway; Cancer research; Tumor progression; Cell adhesion molecule; Downregulation and upregulation; Catenin; Signal transduction; Pathology; Cell biology; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003259851,0.001284759,0.0008851557,0.00345101,0.0005232762,0.001247247,0.0007519034,0.001337289,0.005573637],"category_scores_gemma":[0.0003670043,0.0009297366,0.0007556356,0.000750937,0.001165014,0.0006448105,0.0005172988,0.002704301,0.001223907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008078591,"about_ca_system_score_gemma":0.0005100532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001543691,"about_ca_topic_score_gemma":0.002397378,"domain_scores_codex":[0.9992998,0.00007092248,0.00008988624,0.0002032735,0.0001942148,0.0001419162],"domain_scores_gemma":[0.9984856,0.0001180619,0.0006707328,0.0001141806,0.00008070396,0.0005307523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003380679,0.00004982073,0.0002508377,0.00002644443,0.00001153556,0.0001863191,0.00001625601,0.00003480138,0.9982433,0.0002473342,0.00006204838,0.0005331852],"study_design_scores_gemma":[0.0002141499,0.0004070967,0.01208744,0.00002566506,0.0001173864,0.002491493,0.0001054028,0.001147211,0.9787758,0.0003218105,0.004277559,0.00002903859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898574,0.001746902,0.003853187,0.0004707444,0.0001178589,0.00004052456,0.001813878,0.0005560346,0.001543422],"genre_scores_gemma":[0.981317,0.001508247,0.003317168,0.000250162,0.00007916809,0.0001334096,0.001556334,0.0004488509,0.01138958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005573637,"threshold_uncertainty_score":0.01864564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037322966254797,"score_gpt":0.245199480537871,"score_spread":0.234826250875323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}