{"id":"W2021708038","doi":"10.1021/cb400158t","title":"Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Biology; In silico; Computational biology; RNA; Translation (biology); eIF4A; RNA-binding protein; Eukaryotic translation; Binding site; Helicase; Genetics; Ribosome; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002493687,0.0002698055,0.000262152,0.00002699656,0.0001395537,0.00003706836,0.0005005676,0.000335867,0.0001363201],"category_scores_gemma":[0.002269024,0.0001673023,0.000184746,0.00009605225,0.000423411,0.000008378184,0.0003046579,0.0002402055,0.000202174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004123808,"about_ca_system_score_gemma":0.00003619718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001720297,"about_ca_topic_score_gemma":0.000002266362,"domain_scores_codex":[0.9983448,0.0001060899,0.0003280285,0.0006228895,0.0001024132,0.0004957621],"domain_scores_gemma":[0.9979374,0.001253198,0.0001361083,0.0004294922,0.0001406252,0.0001031872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002294285,0.00005895079,0.0005044594,0.000009416358,0.00005168237,2.393845e-7,0.000004706769,0.000001206602,0.9810733,0.0005067691,0.01603733,0.001522525],"study_design_scores_gemma":[0.0003221628,0.0005402964,0.0005669306,0.00002702274,0.00001366148,0.000009007467,0.0000123121,0.0000586227,0.9604885,0.004879049,0.03281296,0.0002694496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929755,0.000295695,0.0007030474,0.004366123,0.0001177061,0.0005755396,0.00007141136,0.0000409999,0.0008540088],"genre_scores_gemma":[0.9934363,0.0001198692,0.0008053057,0.003854519,0.000550386,0.0004846462,0.0005012652,0.00002107239,0.0002266113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02058476,"threshold_uncertainty_score":0.6822389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08158554552483432,"score_gpt":0.2958154761944414,"score_spread":0.2142299306696071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}