{"id":"W2021725151","doi":"10.1007/s00232-009-9223-z","title":"Mutations in the K+-Channel KcsA Toward Kir Channels Alter Salt-Induced Clusterization and Blockade by Quaternary Alkylammonium Ions","year":2009,"lang":"en","type":"article","venue":"The Journal of Membrane Biology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Austrian Science Fund","keywords":"KcsA potassium channel; Blockade; Ion channel; Ion; Chemistry; Biophysics; Salt (chemistry); Human physiology; Biochemistry; Endocrinology; Biology; Receptor; Physical chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178554,0.0003997985,0.000310469,0.0002012441,0.000332403,0.0004997217,0.0005127254,0.0004507208,0.002013568],"category_scores_gemma":[0.0004147965,0.0002469137,0.0003228441,0.0001672998,0.0007404721,0.0003792846,0.0004764739,0.0008658564,0.0007032654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004764108,"about_ca_system_score_gemma":0.0005008013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001344877,"about_ca_topic_score_gemma":0.001456927,"domain_scores_codex":[0.9997777,0.00003871594,0.00004583474,0.00003638151,0.00005271015,0.00004866053],"domain_scores_gemma":[0.9993039,0.0001359752,0.0002017229,0.00008963084,0.00007439557,0.0001943598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001885509,0.00002670917,0.0001605049,0.00001120386,0.000008461875,0.00005891888,0.0000270567,0.0001264385,0.9986958,0.0002925213,0.00002332066,0.0003805629],"study_design_scores_gemma":[0.0000402433,0.0001868945,0.001827213,0.000009339138,0.0000281025,0.0003333369,0.00005111473,0.001768608,0.99475,0.0001235001,0.0008667533,0.00001503312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997529,0.00008203468,0.001471238,0.00008158038,0.00003177863,0.0000144668,0.00006988476,0.00008174744,0.0006383584],"genre_scores_gemma":[0.9986021,0.00006496037,0.0004999414,0.00004746696,0.000008321916,0.000005285516,0.00004897199,0.00006509296,0.0006578408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013568,"threshold_uncertainty_score":0.00673604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.018282392987933,"score_gpt":0.2674403951540321,"score_spread":0.2491580021660991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}