{"id":"W2021726565","doi":"10.1016/j.maturitas.2007.08.004","title":"A multicenter, prospective, randomized, double-blind, placebo-controlled study to investigate the efficacy of a continuous-combined hormone therapy preparation containing 1 mg estradiol valerate/2 mg dienogest on hot flushes in postmenopausal women","year":2007,"lang":"en","type":"article","venue":"Maturitas","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Bayer (Canada)","funders":"","keywords":"Dienogest; Medicine; Estradiol valerate; Placebo; Hormone replacement therapy (female-to-male); Double blind; Postmenopausal women; Gynecology; Hormone therapy; Valerate; Urology; Menopause; Placebo-controlled study; Internal medicine; Estrogen; Endometriosis; Alternative medicine; Testosterone (patch); Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00224129,0.001534413,0.005022839,0.0006318487,0.0009465078,0.0009403559,0.001264147,0.002406327,0.005080529],"category_scores_gemma":[0.002616629,0.001152469,0.001428447,0.0007117565,0.002365974,0.001112439,0.0005458263,0.002829146,0.0007698778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005333537,"about_ca_system_score_gemma":0.001480639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363046,"about_ca_topic_score_gemma":0.002173329,"domain_scores_codex":[0.9990239,0.0004461513,0.00008844295,0.0002270819,0.00009219074,0.0001221443],"domain_scores_gemma":[0.9982026,0.000590497,0.0002965767,0.0001930957,0.0001380827,0.0005793166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9773187,0.01248697,0.0005287548,0.0003566674,0.0004250287,0.00002436035,0.00004708018,0.00006813231,0.003676381,0.00003045186,0.00013688,0.004900708],"study_design_scores_gemma":[0.8817642,0.1158734,0.001420574,0.00001198056,0.0003245954,0.00001382694,0.00001757169,0.00009539408,0.0003007595,0.00001911573,0.0001493578,0.000009223713],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993167,0.002311884,0.0004893679,0.0002663434,0.0003419298,0.002425766,0.0004335344,0.00006261495,0.0005016329],"genre_scores_gemma":[0.9873515,0.00203589,0.002446004,0.0007879275,0.0007908583,0.004073947,0.0007637995,0.00002337818,0.001726681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005080529,"threshold_uncertainty_score":0.01699603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03354910036003986,"score_gpt":0.3369433706913922,"score_spread":0.3033942703313523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}