{"id":"W2021755139","doi":"10.1021/ja038223n","title":"On the Nature of the Multivalency Effect:  A Thermodynamic Model","year":2003,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":450,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Intramolecular force; Avidity; Entropy (arrow of time); Binding energy; Binding site; Degeneracy (biology); Conformational entropy; Ligand (biochemistry); Molecule; Computational chemistry; Chemical physics; Stereochemistry; Thermodynamics; Receptor; Quantum mechanics; Physics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009557342,0.0005849596,0.0008954394,0.0006237283,0.0005439164,0.0008739816,0.001819703,0.001105702,0.002257004],"category_scores_gemma":[0.001770771,0.0003555471,0.000850477,0.0004217697,0.001759713,0.00213935,0.0006442459,0.001090515,0.0005425574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00135695,"about_ca_system_score_gemma":0.0008803722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001624207,"about_ca_topic_score_gemma":0.0008879051,"domain_scores_codex":[0.9996676,0.000108641,0.00001236169,0.00006254112,0.000103858,0.00004483471],"domain_scores_gemma":[0.999447,0.0003389553,0.00005071127,0.00005449135,0.00007122658,0.00003750894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003331848,0.00006100508,0.0004848959,0.00009146165,0.000029659,0.0001471662,0.0001173898,0.6087944,0.01325086,0.3690458,0.0005287644,0.007415207],"study_design_scores_gemma":[0.000005462347,0.00003322575,0.0001756049,0.000009385079,0.000005632291,0.00002813906,0.00001119748,0.8953125,0.0009572105,0.1023459,0.001098734,0.00001694818],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.09293351,0.001795453,0.887316,0.001784374,0.000121041,0.0001085134,0.0001309452,0.0002058372,0.01560443],"genre_scores_gemma":[0.9148332,0.002068804,0.07096353,0.0005767295,0.0001470549,0.0006383684,0.0001159941,0.0001730019,0.01048344],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002257004,"threshold_uncertainty_score":0.009845376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004261788741335299,"score_gpt":0.2510675980400334,"score_spread":0.2468058092986981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}