{"id":"W2021764678","doi":"10.1038/nrc2819","title":"MYC as a regulator of ribosome biogenesis and protein synthesis","year":2010,"lang":"en","type":"review","venue":"Nature reviews. Cancer","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":979,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Leukemia and Lymphoma Society; Canada Research Chairs; Burroughs Wellcome Fund","keywords":"Ribosome biogenesis; Cell biology; Ribosome; Ribosomal protein; 5.8S ribosomal RNA; Biology; Regulator; Ribosomal RNA; Translation (biology); Transcription (linguistics); RNA; Messenger RNA; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004779746,0.001075483,0.001330245,0.001456501,0.0003290093,0.001148196,0.001434378,0.001655576,0.002236527],"category_scores_gemma":[0.0003387709,0.0004025307,0.000304624,0.002262187,0.0009198806,0.001431303,0.0008735848,0.002032626,0.002498775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001167942,"about_ca_system_score_gemma":0.0008629271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007582595,"about_ca_topic_score_gemma":0.001542303,"domain_scores_codex":[0.9998263,0.00002323232,0.00001562144,0.00003736704,0.0000735639,0.00002406322],"domain_scores_gemma":[0.9998073,0.00006492047,0.00003465475,0.00001011822,0.00004846209,0.00003447144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000211003,0.00005223588,0.0002166871,0.007067771,0.00007673603,0.0003552125,0.00004259081,0.0008117486,0.01381402,0.01542964,0.05894526,0.9029772],"study_design_scores_gemma":[0.0000207064,0.00004057202,0.0006339745,0.0008101242,0.0000389917,0.001145394,0.00002962874,0.0001443289,0.002009747,0.00392184,0.9911888,0.00001595984],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001525879,0.9975007,0.0002488554,0.0003609227,0.0003966234,0.000002956847,0.00001635418,0.00001161709,0.001309347],"genre_scores_gemma":[0.001350304,0.9968886,0.000173935,0.0002304636,0.0003072114,0.000005963849,0.00003761728,0.000001928474,0.001003917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002236527,"threshold_uncertainty_score":0.008474052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965517126202446,"score_gpt":0.3458551108534167,"score_spread":0.3261999395913922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}