{"id":"W2021770899","doi":"10.1016/j.clgc.2014.11.001","title":"First-Line and Sequential Use of Pazopanib Followed by Mammalian Target of Rapamycin Inhibitor Therapy Among Patients With Advanced Renal Cell Carcinoma in a US Community Oncology Setting","year":2014,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Centre for Applied Research in Cancer Control; GlaxoSmithKline","keywords":"Pazopanib; Medicine; Temsirolimus; Everolimus; Internal medicine; Oncology; Adverse effect; Renal cell carcinoma; Cohort; Nausea; Clinical trial; Sunitinib; PI3K/AKT/mTOR pathway; Discovery and development of mTOR inhibitors","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533309,0.0001774571,0.0005751484,0.0003959275,0.0007014665,0.0005672903,0.0002770986,0.0003800887,0.001249086],"category_scores_gemma":[0.001571579,0.0001751956,0.0004873396,0.0008416256,0.0002250905,0.0005042751,0.0002609449,0.0007171886,0.00009518282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00116362,"about_ca_system_score_gemma":0.002177823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008919069,"about_ca_topic_score_gemma":0.03756954,"domain_scores_codex":[0.9996333,0.00008429788,0.00003137564,0.00008867025,0.00006244696,0.00009991871],"domain_scores_gemma":[0.9993852,0.0001132586,0.0001958187,0.00001558737,0.00005306712,0.0002370005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005286478,0.001157778,0.944829,0.0001512172,0.0002799593,0.0006577987,0.0001330441,0.0005151978,0.002498623,0.00008079692,0.001557074,0.04285302],"study_design_scores_gemma":[0.000596397,0.004627984,0.9868507,0.00006312146,0.0004074275,0.002395393,0.0006279744,0.001531216,0.0008413337,0.0001950548,0.00184095,0.00002233026],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963483,0.00165999,0.00008438182,0.0002971784,0.00002199605,0.00004655045,0.0002619226,0.00001122258,0.001268449],"genre_scores_gemma":[0.998907,0.0004026308,0.0001296531,0.0001889468,0.00002419393,0.00001312449,0.0002066901,0.000002498595,0.0001252617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008919069,"threshold_uncertainty_score":0.01773429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04026818035067124,"score_gpt":0.3145901358223183,"score_spread":0.274321955471647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}