{"id":"W2021775249","doi":"10.1093/nar/28.18.3625","title":"2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies","year":2000,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oligonucleotide; RNA; RNase H; DNA; RNase P; Base pair; Biology; Stereochemistry; Circular dichroism; Duplex (building); Polynucleotide; Crystallography; Nucleic acid thermodynamics; Molecular biology; Biochemistry; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002180553,0.0004035821,0.0001375379,0.0001295084,0.0001075868,0.0001576938,0.0001341401,0.0003535714,0.0004783704],"category_scores_gemma":[0.0002810875,0.0001573003,0.0001414037,0.0001116491,0.0001411808,0.0002017661,0.00006554184,0.000232001,0.0002881157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001377408,"about_ca_system_score_gemma":0.0001268006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003125979,"about_ca_topic_score_gemma":0.0006048428,"domain_scores_codex":[0.999859,0.00004175447,0.000009162413,0.00003884151,0.00003415599,0.00001699406],"domain_scores_gemma":[0.9998623,0.00005854462,0.00003018587,0.00000774027,0.00001953954,0.00002163455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002111678,0.000009667337,0.00007740905,0.00003573115,0.000002535883,0.00002564974,0.0000103659,0.0001170072,0.9984021,0.00003591386,0.000007947616,0.001254693],"study_design_scores_gemma":[0.000004368046,0.0002129656,0.001217965,0.000003200714,0.00000539271,0.0003033799,0.000009239024,0.0003273175,0.9957036,0.000028277,0.00217654,0.00000770222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628381,0.00888778,0.02511635,0.00009450661,0.00003604934,0.0001142178,0.0002695997,0.00009592744,0.002547474],"genre_scores_gemma":[0.95971,0.003787491,0.03344182,0.0000947144,0.00002669449,0.0001071929,0.0005599476,0.00002767324,0.002244586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004783704,"threshold_uncertainty_score":0.001600266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03564590456482301,"score_gpt":0.3301005343452235,"score_spread":0.2944546297804004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}