{"id":"W2021775249","doi":"10.1093/nar/28.18.3625","title":"2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies","year":2000,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oligonucleotide; RNA; RNase H; DNA; RNase P; Base pair; Biology; Stereochemistry; Circular dichroism; Duplex (building); Polynucleotide; Crystallography; Nucleic acid thermodynamics; Molecular biology; Biochemistry; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006878017,0.0003493999,0.0004311354,0.00008450379,0.0004496548,0.0001321095,0.0004077353,0.0003033013,0.0003320005],"category_scores_gemma":[0.0003669933,0.0003184059,0.0001097092,0.0002244086,0.001579755,0.00002386792,0.0005047554,0.0004139509,0.00008674865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003628763,"about_ca_system_score_gemma":0.00005547314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002933218,"about_ca_topic_score_gemma":0.000005195569,"domain_scores_codex":[0.9972771,0.0001755196,0.0003271049,0.0009322168,0.0005020328,0.0007860637],"domain_scores_gemma":[0.998549,0.0001881909,0.00004733813,0.0006695912,0.0002175589,0.0003282551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000223542,0.0001145127,0.002884076,0.0001618626,0.000264006,0.00001971341,0.0002572888,0.000001382117,0.9083022,0.0001610249,0.01207337,0.075537],"study_design_scores_gemma":[0.0006321392,0.000283449,0.00468599,0.0001068972,0.00006297381,0.00009311023,0.001114741,0.00006283133,0.9376689,0.0007281932,0.05403168,0.0005290715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983766,0.005822748,0.000002391845,0.0009230947,0.00003149289,0.000201457,0.00002513687,0.00004851559,0.009179219],"genre_scores_gemma":[0.987788,0.008364138,0.0007620202,0.0002029535,0.0003940794,0.00006712841,0.00001542581,0.00007468415,0.002331629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07500792,"threshold_uncertainty_score":0.9999268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03564590456482301,"score_gpt":0.3301005343452235,"score_spread":0.2944546297804004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}